Malaria in pregnancy: Meta-analyses of prevalence and associated complications.

IF 2.5 4区 医学 Q3 INFECTIOUS DISEASES
Jai K Das, Sohail Lakhani, Abdu R Rahman, Faareha Siddiqui, Zahra Ali Padhani, Zainab Rashid, Omar Mahmud, Syeda Kanza Naqvi, Hamna Amir Naseem, Hamzah Jehanzeb, Suresh Kumar, Mohammad Asim Beg
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Abstract

This review aims to assess the prevalence of malaria in pregnancy during antenatal visits and delivery, species-specific burden together with regional variation in the burden of disease. It also aims to estimate the proportions of adverse pregnancy outcomes in malaria-positive women. Based on the PRISMA guidelines, a thorough and systematic search was conducted in July 2023 across two electronic databases (including PubMed and CENTRAL). Forest plots were constructed for each outcome of interest highlighting the effect measure, confidence interval, sample size, and its associated weightage. All the statistical meta-analysis were conducted using R-Studio version 2022.07. Sensitivity analyses, publication bias assessment, and meta-regression analyses were also performed to ensure robustness of the review. According to the pooled estimates of 253 studies, the overall prevalence of malaria was 18.95% (95% CI: 16.95-21.11), during antenatal visits was 20.09% (95% CI: 17.43-23.06), and at delivery was 17.32% (95% CI: 14.47-20.61). The highest proportion of malarial infection was observed in Africa approximating 21.50% (95% CI: 18.52-24.81) during ANC and 20.41% (95% CI: 17.04-24.24) at the time of delivery. Our analysis also revealed that the odds of having anaemia were 2.40 times (95% CI: 1.87-3.06), having low birthweight were 1.99 times (95% CI: 1.60-2.48), having preterm birth were 1.65 times (95% CI: 1.29-2.10), and having stillbirths were 1.40 times (95% CI: 1.15-1.71) in pregnant women with malaria.

妊娠期疟疾:妊娠期疟疾:发病率和相关并发症的 Meta 分析。
本综述旨在评估产前检查和分娩期间妊娠期疟疾的发病率、特定物种的负担以及疾病负担的地区差异。它还旨在估算疟疾阳性妇女不良妊娠结局的比例。根据 PRISMA 指南,我们于 2023 年 7 月在两个电子数据库(包括 PubMed 和 CENTRAL)中进行了全面系统的搜索。为每个相关结果绘制了森林图,突出显示了效果测量、置信区间、样本大小及其相关权重。所有统计荟萃分析均使用 R-Studio 2022.07 版本进行。此外,还进行了敏感性分析、发表偏倚评估和元回归分析,以确保综述的稳健性。根据对 253 项研究的汇总估计,疟疾的总体流行率为 18.95%(95% CI:16.95-21.11),产前检查期间为 20.09%(95% CI:17.43-23.06),分娩时为 17.32%(95% CI:14.47-20.61)。非洲的疟疾感染率最高,在产前检查期间为 21.50%(95% CI:18.52-24.81),分娩时为 20.41%(95% CI:17.04-24.24)。我们的分析还显示,疟疾孕妇患贫血的几率是普通孕妇的 2.40 倍(95% CI:1.87-3.06),患低出生体重的几率是普通孕妇的 1.99 倍(95% CI:1.60-2.48),患早产的几率是普通孕妇的 1.65 倍(95% CI:1.29-2.10),患死胎的几率是普通孕妇的 1.40 倍(95% CI:1.15-1.71)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Epidemiology and Infection
Epidemiology and Infection 医学-传染病学
CiteScore
4.10
自引率
2.40%
发文量
366
审稿时长
3-6 weeks
期刊介绍: Epidemiology & Infection publishes original reports and reviews on all aspects of infection in humans and animals. Particular emphasis is given to the epidemiology, prevention and control of infectious diseases. The scope covers the zoonoses, outbreaks, food hygiene, vaccine studies, statistics and the clinical, social and public-health aspects of infectious disease, as well as some tropical infections. It has become the key international periodical in which to find the latest reports on recently discovered infections and new technology. For those concerned with policy and planning for the control of infections, the papers on mathematical modelling of epidemics caused by historical, current and emergent infections are of particular value.
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