Cytokines (IL1β, IL6, TNFα) and serum cortisol levels may not constitute reliable biomarkers to identify individuals with post-acute sequelae of COVID-19.

IF 5.4 3区材料科学 Q2 CHEMISTRY, PHYSICAL

ACS Applied Energy Materials Pub Date : 2024-02-12 eCollection Date: 2024-01-01 DOI:10.1177/17562864241229567

Michael Fleischer, Fabian Szepanowski, Anne K Mausberg, Livia Asan, Ellen Uslar, Denise Zwanziger, Lothar Volbracht, Mark Stettner, Christoph Kleinschnitz

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引用次数: 0

Abstract

Background: Post-acute sequelae of COVID-19 (PASC) comprise a broad spectrum of symptoms such as fatigue, general weakness, compromised attention and sleep or anxiety disorders. PASC represents a medical and socio-economic challenge.

Objectives: Our study evaluated cytokines (IL-1β, IL-6 and TNFα) and cortisol levels in a cohort of typical patients with PASC, suffering concentration problems, fatigue and difficulties finding words.

Design: This was a prospective cohort study. Four groups were analysed and compared: those who had never contracted SARS-CoV-2 (n = 13), infected but had no PASC (n = 34), infected with former PASC that resolved (n = 40) and patients with ongoing PASC after infection (n = 91).

Methods: Cytokine and cortisol serum levels were determined in patients' blood samples.

Results: Cytokine levels of IL-1β, IL-6, TNFα and cortisol levels did not differ between groups analysed.

Conclusion: This may indicate a non-organic/psychosomatic genesis of PASC; further studies are needed to elucidate the underlying causes of PACS, and non-organic causes should not be overlooked.

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细胞因子（IL1β、IL6、TNFα）和血清皮质醇水平可能不是识别 COVID-19 急性后遗症患者的可靠生物标志物。

背景：COVID-19 急性后遗症（PASC）包括一系列症状，如疲劳、全身无力、注意力不集中、睡眠或焦虑症。PASC 是一项医疗和社会经济挑战：我们的研究评估了一组典型 PASC 患者的细胞因子（IL-1β、IL-6 和 TNFα）和皮质醇水平：这是一项前瞻性队列研究。对四组患者进行了分析和比较：从未感染过 SARS-CoV-2 的患者（n = 13）、感染过但没有 PASC 的患者（n = 34）、感染过但 PASC 已缓解的患者（n = 40）和感染后 PASC 仍在持续的患者（n = 91）：方法：测定患者血样中的细胞因子和皮质醇血清水平：结果：IL-1β、IL-6、TNFα等细胞因子水平和皮质醇水平在分析组间无差异：结论：这可能表明 PASC 是一种非器质性/心身性疾病；需要进一步研究以阐明 PACS 的根本原因，不应忽视非器质性原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.