Cytokines (IL1β, IL6, TNFα) and serum cortisol levels may not constitute reliable biomarkers to identify individuals with post-acute sequelae of COVID-19.

IF 4.7 2区医学 Q1 CLINICAL NEUROLOGY

Therapeutic Advances in Neurological Disorders Pub Date : 2024-02-12 eCollection Date: 2024-01-01 DOI:10.1177/17562864241229567

Michael Fleischer, Fabian Szepanowski, Anne K Mausberg, Livia Asan, Ellen Uslar, Denise Zwanziger, Lothar Volbracht, Mark Stettner, Christoph Kleinschnitz

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引用次数: 0

Abstract

Background: Post-acute sequelae of COVID-19 (PASC) comprise a broad spectrum of symptoms such as fatigue, general weakness, compromised attention and sleep or anxiety disorders. PASC represents a medical and socio-economic challenge.

Objectives: Our study evaluated cytokines (IL-1β, IL-6 and TNFα) and cortisol levels in a cohort of typical patients with PASC, suffering concentration problems, fatigue and difficulties finding words.

Design: This was a prospective cohort study. Four groups were analysed and compared: those who had never contracted SARS-CoV-2 (n = 13), infected but had no PASC (n = 34), infected with former PASC that resolved (n = 40) and patients with ongoing PASC after infection (n = 91).

Methods: Cytokine and cortisol serum levels were determined in patients' blood samples.

Results: Cytokine levels of IL-1β, IL-6, TNFα and cortisol levels did not differ between groups analysed.

Conclusion: This may indicate a non-organic/psychosomatic genesis of PASC; further studies are needed to elucidate the underlying causes of PACS, and non-organic causes should not be overlooked.

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细胞因子（IL1β、IL6、TNFα）和血清皮质醇水平可能不是识别 COVID-19 急性后遗症患者的可靠生物标志物。

背景：COVID-19 急性后遗症（PASC）包括一系列症状，如疲劳、全身无力、注意力不集中、睡眠或焦虑症。PASC 是一项医疗和社会经济挑战：我们的研究评估了一组典型 PASC 患者的细胞因子（IL-1β、IL-6 和 TNFα）和皮质醇水平：这是一项前瞻性队列研究。对四组患者进行了分析和比较：从未感染过 SARS-CoV-2 的患者（n = 13）、感染过但没有 PASC 的患者（n = 34）、感染过但 PASC 已缓解的患者（n = 40）和感染后 PASC 仍在持续的患者（n = 91）：方法：测定患者血样中的细胞因子和皮质醇血清水平：结果：IL-1β、IL-6、TNFα等细胞因子水平和皮质醇水平在分析组间无差异：结论：这可能表明 PASC 是一种非器质性/心身性疾病；需要进一步研究以阐明 PACS 的根本原因，不应忽视非器质性原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Therapeutic Advances in Neurological Disorders CLINICAL NEUROLOGY-

CiteScore

8.30

自引率

1.70%

发文量

审稿时长

15 weeks

期刊介绍： Therapeutic Advances in Neurological Disorders is a peer-reviewed, open access journal delivering the highest quality articles, reviews, and scholarly comment on pioneering efforts and innovative studies across all areas of neurology. The journal has a strong clinical and pharmacological focus and is aimed at clinicians and researchers in neurology, providing a forum in print and online for publishing the highest quality articles in this area.