Global prevalence and risk factors of Enterocytozoon bieneusi infection in humans: a systematic review and meta-analysis.

IF 2.3 2区医学 Q2 PARASITOLOGY

Parasite Pub Date : 2024-01-01 Epub Date: 2024-02-09 DOI:10.1051/parasite/2024007

Yanchun Wang, Xiao-Man Li, Xing Yang, Xiang-Yu Wang, Yong-Jie Wei, Yanan Cai, Hong-Li Geng, Xin-Bo Yang, Hai-Long Yu, Hongwei Cao, Jing Jiang

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Abstract

Enterocytozoon bieneusi is one of the most important zoonotic pathogens. In this study, we present a systematic review and meta-analysis of the prevalence of human E. bieneusi infection in endemic regions and analyze the various potential risk factors. A total of 75 studies were included. Among 31,644 individuals tested, 2,291 (6.59%) were E. bieneusi-positive. The highest prevalence of E. bieneusi in the male population was 5.50%. The prevalence of E. bieneusi in different age groups was varied, with 10.97% in teenagers. The prevalence of E. bieneusi in asymptomatic patients (6.49%) is significantly lower than that in HIV-infected patients (11.49%), and in patients with diarrheal symptoms (16.45%). Rural areas had a higher rate (7.58%) than urban ones. The prevalence of E. bieneusi in humans was the highest (6.42%) at altitudes <10 m. Moreover, the temperate zone marine climate (13.55%) had the highest prevalence. A total of 69 genotypes of E. bieneusi have been found in humans. This is the first global study regarding E. bieneusi prevalence in humans. Not only people with low immunity (such as the elderly, children, people with HIV, etc.), but also people in Europe in temperate marine climates should exercise caution to prevent infection with E. bieneusi during contact process with animals.

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生物肠虫感染的全球流行率和风险因素：系统回顾和荟萃分析。

生物肠杆菌是最重要的人畜共患病原体之一。在本研究中，我们对流行地区人感染生物肠杆菌的情况进行了系统回顾和荟萃分析，并分析了各种潜在的风险因素。共纳入 75 项研究。在接受检测的 31,644 人中，2,291 人（6.59%）为 E. bieneusi 阳性。男性人群中生物酵母菌的最高感染率为 5.50%。不同年龄段人群的生物酵母菌感染率各不相同，青少年的感染率为 10.97%。无症状患者的生物弧菌感染率（6.49%）明显低于艾滋病毒感染者（11.49%）和有腹泻症状的患者（16.45%）。农村地区的感染率（7.58%）高于城市地区。在海拔较高的地区，E. bieneusi 在人类中的流行率最高（6.42%）。

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来源期刊

Parasite 医学-寄生虫学

CiteScore

5.50

自引率

6.90%

发文量

审稿时长

3 months

期刊介绍： Parasite is an international open-access, peer-reviewed, online journal publishing high quality papers on all aspects of human and animal parasitology. Reviews, articles and short notes may be submitted. Fields include, but are not limited to: general, medical and veterinary parasitology; morphology, including ultrastructure; parasite systematics, including entomology, acarology, helminthology and protistology, and molecular analyses; molecular biology and biochemistry; immunology of parasitic diseases; host-parasite relationships; ecology and life history of parasites; epidemiology; therapeutics; new diagnostic tools. All papers in Parasite are published in English. Manuscripts should have a broad interest and must not have been published or submitted elsewhere. No limit is imposed on the length of manuscripts, but they should be concisely written. Papers of limited interest such as case reports, epidemiological studies in punctual areas, isolated new geographical records, and systematic descriptions of single species will generally not be accepted, but might be considered if the authors succeed in demonstrating their interest.