Fatty Liver, Statin Therapy, and the Risk of Hypertriglyceridemic Acute Pancreatitis: A Retrospective Study.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-04-01 Epub Date: 2024-02-12 DOI:10.1097/MPA.0000000000002305

Chunyan Chen, Yu Zhang, Zhengdong Ding, Suyan Zhu

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引用次数: 0

Abstract

Objectives: Identifying patients with severe hypertriglyceridemia (HTG) who are prone to developing hypertriglyceridemic pancreatitis (HTGP) is essential for facilitating preventative interventions. This research aims to explore which part of the HTG patients is easy to develop into HTGP.

Materials and methods: An observational cohort study was conducted in patients with serum triglycerides (TGs) ≥ 5.65 mmol/L. Propensity score matching (PSM) and logistic regression were used to adjust for potential confounding factors. Receiver operating characteristic (ROC) curves were applied to evaluate the predictive potential for HTGP.

Results: A total of 283 patients were included finally with a PSM cohort consisting of 55 HTGP matched with 77 non-HTGP. In multivariate logistic regression analysis, fatty liver (FL) (odds ratio, 2.535; P = 0.019) showed statistically significant association with HTGP, whereas statin use was correlated with a lower rate of HTGP (odds ratio, 0.203; P = 0.009). Finally, the ROC analysis showed that the TGs threshold thought to be causal of HTGP in patients with FL was significantly lower (9.31 vs 14.67 mmol/L) than that in patients without FL.

Conclusions: Although with lower TGs levels, patients with FL are much more prone to generate HTGP, and our findings suggest a potential role of statin as protective agents against HTGP.

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脂肪肝、他汀类药物治疗与高甘油三酯急性胰腺炎的风险：一项回顾性研究。

目的：识别容易发展为高甘油三酯性胰腺炎（HTGP）的严重高甘油三酯血症（HTG）患者对于促进预防性干预至关重要。本研究旨在探讨高甘油三酯血症患者中哪一部分容易发展为高甘油三酯性胰腺炎：对血清甘油三酯（TGs）≥ 5.65 mmol/L的患者进行观察性队列研究。采用倾向评分匹配（PSM）和逻辑回归调整潜在的混杂因素。应用接收者操作特征曲线（ROC）评估高血脂症的预测潜力：最后共纳入 283 名患者，其中 55 名 HTGP 患者与 77 名非 HTGP 患者进行了 PSM 配对。在多变量逻辑回归分析中，脂肪肝（FL）（几率比，2.535；P = 0.019）与 HTGP 有显著的统计学关联，而他汀类药物的使用与较低的 HTGP 发生率相关（几率比，0.203；P = 0.009）。最后，ROC分析表明，FL患者被认为导致高血压的总胆固醇阈值（9.31 vs 14.67 mmol/L）明显低于非FL患者：结论：虽然 FL 患者的 TGs 水平较低，但他们更容易产生 HTGP。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.