Subcutaneous Bolus Infusions of Undiluted Levetiracetam for End-of-Life Patients: Two Cases.

IF 0.9 Q3 ANESTHESIOLOGY
Kenneth Skov, Astrid Lyager
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引用次数: 0

Abstract

We present two cases, in which end-of-life patients were inadvertently treated with bolus infusions of undiluted subcutaneous levetiracetam. The patients were treated for three and four days respectively. In both cases, the course of treatment was uneventful. Especially, no seizures, nor local irritation was observed. Administration of undiluted subcutaneous levetiracetam as intermittent bolus infusions by hand holds alluring properties for end-of-life patients. Amongst others reducing patient discomfort, increasing freedom of movement, and accessibility to essential seizure prophylaxis by eliminating the need for a syringe driver, thereby helping accommodate many patients wish to die in their own home. However, pharmacokinetics, efficacy, and safety, including the optimum dilution and administration time of the subcutaneous preparation remains to be determined in clinically controlled trials.

为临终患者皮下注射未稀释的左乙拉西坦:两个病例
我们介绍了两个病例,其中临终患者无意中接受了未经稀释的皮下注射左乙拉西坦的治疗。患者分别接受了三天和四天的治疗。两个病例的治疗过程都很顺利。尤其是没有观察到癫痫发作,也没有观察到局部刺激。对临终患者而言,以间歇性栓剂输注的方式进行未稀释的皮下注射左乙拉西坦具有诱人的特性。其中包括减少病人的不适感,增加行动自由,以及通过消除对注射器驱动器的需求来获得必要的癫痫预防,从而帮助满足许多病人在自己家中去世的愿望。然而,药代动力学、疗效和安全性,包括皮下注射制剂的最佳稀释度和给药时间,仍有待临床对照试验来确定。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.60
自引率
9.10%
发文量
40
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