From Software to Hardware: A Case Series of Functional Neurological Symptoms and Cerebrovascular Disease.

IF 2.4 4区医学 Q2 CLINICAL NEUROLOGY

Journal of Neuropsychiatry and Clinical Neurosciences Pub Date : 2024-01-01 Epub Date: 2024-02-12 DOI:10.1176/appi.neuropsych.20220182

Jan Coebergh, Shabana Habib, Tiago Teodoro, Mark Edwards, Matt Butler

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引用次数: 0

Abstract

Objective: Neuroimaging studies have identified alterations in both brain structure and functional connectivity in patients with functional neurological disorder (FND). For many patients, FND emerges from physical precipitating events. Nevertheless, there are a limited number of case series in the literature that describe the clinical presentation and neuroimaging correlates of FND following cerebrovascular disease.

Methods: The authors collected data from two clinics in the United Kingdom on 14 cases of acute, improving, or delayed functional neurological symptoms following cerebrovascular events.

Results: Most patients had functional neurological symptoms that were localized to cerebrovascular lesions, and the lesions mapped onto regions known to be part of functional networks disrupted in FND, including the thalamus, anterior cingulate gyrus, insula, and temporoparietal junction.

Conclusions: The findings demonstrate that structural lesions can lead to FND symptoms, possibly explained through changes in relevant mechanistic functional networks.

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从软件到硬件：功能性神经症状和脑血管疾病病例系列。

目的：神经影像学研究发现，功能性神经障碍（FND）患者的大脑结构和功能连接都发生了改变。对于许多患者来说，功能性神经紊乱是由身体诱发事件引起的。然而，文献中描述脑血管疾病后 FND 的临床表现和神经影像学相关性的系列病例数量有限：作者从英国的两家诊所收集了 14 例脑血管事件后急性、改善或延迟功能性神经症状病例的数据：结果：大多数患者的功能性神经症状定位在脑血管病变部位，病变部位映射到已知是 FND 功能性网络破坏的一部分的区域，包括丘脑、扣带回前部、脑岛和颞顶交界处：结论：研究结果表明，结构性病变可导致 FND 症状，而相关机制性功能网络的变化可能是导致 FND 症状的原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Neuropsychiatry and Clinical Neurosciences 医学-精神病学

CiteScore

5.30

自引率

3.40%

发文量

审稿时长

6-12 weeks

期刊介绍： As the official Journal of the American Neuropsychiatric Association, the premier North American organization of clinicians, scientists, and educators specializing in behavioral neurology & neuropsychiatry, neuropsychology, and the clinical neurosciences, the Journal of Neuropsychiatry and Clinical Neurosciences (JNCN) aims to publish works that advance the science of brain-behavior relationships, the care of persons and families affected by neurodevelopmental, acquired neurological, and neurodegenerative conditions, and education and training in behavioral neurology & neuropsychiatry. JNCN publishes peer-reviewed articles on the cognitive, emotional, and behavioral manifestations of neurological conditions, the structural and functional neuroanatomy of idiopathic psychiatric disorders, and the clinical and educational applications and public health implications of scientific advances in these areas. The Journal features systematic reviews and meta-analyses, narrative reviews, original research articles, scholarly considerations of treatment and educational challenges in behavioral neurology & neuropsychiatry, analyses and commentaries on advances and emerging trends in the field, international perspectives on neuropsychiatry, opinions and introspections, case reports that inform on the structural and functional bases of neuropsychiatric conditions, and classic pieces from the field’s rich history.