Growth Differentiation Factor-15 and Clinical Outcomes in Lower Extremity Artery Disease.

IF 3 2区 医学 Q2 PERIPHERAL VASCULAR DISEASE
Journal of atherosclerosis and thrombosis Pub Date : 2024-06-01 Epub Date: 2024-01-31 DOI:10.5551/jat.64515
Taku Shikama, Yoichiro Otaki, Tetsu Watanabe, Harutoshi Tamura, Shigehiko Kato, Satoshi Nishiyama, Hiroki Takahashi, Takanori Arimoto, Masafumi Watanabe
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引用次数: 0

Abstract

Aim: Lower extremity artery disease (LEAD) is an increasingly common health problem that is associated with high mortality due to thrombotic and bleeding events. Growth differentiation factor-15 (GDF15), a stress-response cytokine belonging to the transforming growth factor-beta superfamily, is associated with cardiovascular disease and its outcomes. The aim of the present study was to examine the effect of serum GDF15 levels on clinical outcomes in patients with LEAD.

Methods: We measured serum GDF15 levels in 200 patients with LEAD before their initial endovascular therapy. The primary endpoint was the all-cause mortality rate. The secondary endpoints, on the other hand, were thrombotic and bleeding events, such as cerebral infarction, acute coronary syndrome, acute limb ischemia, and Bleeding Academic Research Consortium types 3 and 5.

Results: The serum GDF15 levels increased with advancing Fontaine class. Kaplan-Meier analysis revealed that the high-GDF15 group (≥ 2,275 pg/mL) had higher rates of all-cause deaths and thrombotic and bleeding events than the low-GDF15 group (<2,275 pg/mL). Multivariate Cox proportional-hazards regression analysis revealed that GDF15 was an independent predictor of all-cause mortality and thrombotic and bleeding events after adjusting for confounding risk factors. When the ABC-AF-bleeding score was substituted for GDF15, similar results were obtained.

Conclusion: Serum GDF15 levels were associated with all-cause mortality and thrombotic and bleeding events in patients with LEAD. Serum GDF15 is a potentially useful marker of clinical outcomes, specifically for tracking thrombotic and bleeding events in patients with LEAD.

生长分化因子-15 与下肢动脉疾病的临床预后
目的:下肢动脉疾病(LEAD)是一种日益常见的健康问题,与血栓和出血事件导致的高死亡率有关。生长分化因子-15(GDF15)是一种应激反应细胞因子,属于转化生长因子-β超家族,与心血管疾病及其预后有关。本研究旨在探讨血清 GDF15 水平对 LEAD 患者临床预后的影响:我们在200名LEAD患者接受首次血管内治疗前测定了他们的血清GDF15水平。主要终点是全因死亡率。次要终点则是血栓和出血事件,如脑梗塞、急性冠状动脉综合征、急性肢体缺血以及出血学术研究联盟 3 型和 5 型:结果:血清GDF15水平随着方丹分级的升高而升高。Kaplan-Meier分析显示,与低GDF15组(<2,275 pg/mL)相比,高GDF15组(≥2,275 pg/mL)的全因死亡率、血栓和出血事件发生率更高。多变量 Cox 比例危险回归分析显示,在调整了混杂风险因素后,GDF15 是全因死亡率、血栓和出血事件的独立预测因子。当用ABC-AF-出血评分代替GDF15时,也得到了类似的结果:结论:血清GDF15水平与LEAD患者的全因死亡率、血栓和出血事件有关。血清GDF15是临床结果的潜在有用标记物,特别是可用于追踪LEAD患者的血栓和出血事件。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.60
自引率
15.90%
发文量
271
审稿时长
1 months
期刊介绍: JAT publishes articles focused on all aspects of research on atherosclerosis, vascular biology, thrombosis, lipid and metabolism.
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