The effect of soy isoflavones in brain development: the emerging role of multiple signaling pathways and future perspectives.

IF 1.3 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM
Endocrine journal Pub Date : 2024-04-30 Epub Date: 2024-03-10 DOI:10.1507/endocrj.EJ23-0314
Winda Ariyani, Noriyuki Koibuchi
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引用次数: 0

Abstract

Soybean is a source of protein, fibers, and phytochemical isoflavones which are considered to have numerous health benefits for children and adulthood. On the other hand, isoflavones are widely known as phytoestrogens that exert their action via the estrogen signaling pathway. With this regard, isoflavones are also considered as endocrine-disrupting chemicals. Endogenous estrogen plays a crucial role in brain development through binding to estrogen receptors (ERs) or G protein-coupled estrogen receptors 1 (GPER1) and regulates morphogenesis, migration, functional maturation, and intracellular metabolism of neurons and glial cells. Soy isoflavones can also bind to ERs, GPER1, and, furthermore, other receptors to modulate their action. Therefore, soy isoflavone consumption may affect brain development during the pre-and post-natal periods. This review summarizes the current knowledge on the mechanisms of isoflavone action, particularly in the early stages of brain development by introducing representative human, and animal models, and in vitro studies, and discusses their beneficial and adverse impact on neurobehavior. As a conclusion, the soy product consumption during the pre-and post-natal periods under proper range of dose showed beneficial effects in neurobehavior development, including improvement of anxiety, aggression, hyperactive behavior, and cognition, whereas their adverse effect by taking higher doses cannot be excluded. We also present novel research lines to further assess the effect of soy isoflavone administration during brain development.

大豆异黄酮对大脑发育的影响:多种信号通路的新作用和未来展望。
大豆是蛋白质、纤维和植物化学物质异黄酮的来源,这些物质被认为对儿童和成年人的健康有诸多益处。另一方面,异黄酮是广为人知的植物雌激素,可通过雌激素信号途径发挥作用。因此,异黄酮也被认为是干扰内分泌的化学物质。内源性雌激素通过与雌激素受体(ER)或 G 蛋白偶联雌激素受体 1(GPER1)结合,在大脑发育过程中发挥着至关重要的作用,并调节神经元和胶质细胞的形态发生、迁移、功能成熟和细胞内代谢。大豆异黄酮还能与 ERs、GPER1 以及其他受体结合,从而调节它们的作用。因此,食用大豆异黄酮可能会影响出生前和出生后的大脑发育。本综述通过介绍具有代表性的人体、动物模型和体外研究,总结了当前有关异黄酮作用机制的知识,尤其是在大脑发育早期阶段的作用机制,并讨论了其对神经行为的有利和不利影响。结论是,在适当的剂量范围内,产前和产后食用大豆制品对神经行为发育有益处,包括改善焦虑、攻击性、多动行为和认知能力,但也不排除高剂量食用会产生不良影响。我们还提出了新的研究思路,以进一步评估大豆异黄酮在大脑发育过程中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Endocrine journal
Endocrine journal 医学-内分泌学与代谢
CiteScore
4.30
自引率
5.00%
发文量
224
审稿时长
1.5 months
期刊介绍: Endocrine Journal is an open access, peer-reviewed online journal with a long history. This journal publishes peer-reviewed research articles in multifaceted fields of basic, translational and clinical endocrinology. Endocrine Journal provides a chance to exchange your ideas, concepts and scientific observations in any area of recent endocrinology. Manuscripts may be submitted as Original Articles, Notes, Rapid Communications or Review Articles. We have a rapid reviewing and editorial decision system and pay a special attention to our quick, truly scientific and frequently-citable publication. Please go through the link for author guideline.
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