Arno Rusel Donfack Nanfack , Ariane Audrey Sinze Metiave , Faustine Léonie Mafodong Dongmo , Mehreen Lateef , Maurice Ducret Awouafack , Silvère Augustin Ngouela , Muhammad Shaiq Ali , Mathieu Tene
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引用次数: 0
Abstract
The phytochemical investigation of the methanolic extract of the leaves of Hymenocardia acida (Euphorbiaceae) resulted in the isolation of twelve known secondary metabolites including flavonolignan (1), coumarin (2), chromone (3), C-glucosylated flavonoid (4), bisphenylpropanoid (5), triterpenoids (6–9) and steroids (10–12), respectively. Their structures were elucidated by comparison of their physical and spectroscopic data with those reported in literature. This is the first report on isolation of compounds 1–5 and 10 from the family Euphorbiaceae. The chemotaxonomic significance of these compounds has been discussed. Hydnocarpin (1), 7-hydroxycoumarin (2), 5,7-dihydroxy-2-n-pentacosanylchrom-4-one (3), luteolin 6-C-β-D-glucopyranoside (4), katsumadin (5) and friedelanone (6), were evaluated in vitro for their anti-free radical scavenging activity as well as inhibitory potential against the enzyme urease. Compounds 4 and 5 exhibited potent anti-free radical scavenging activity (IC50 = 20.20 ± 0.19 μM and 15.60 ± 0.22 μM, respectively), while compounds 1–4 showed significant urease inhibitory activity (IC50 = 25.60 ± 0.59 μM, 33.20 ± 0.73 μM, 27.60 ± 0.69 μM and 26.60 ± 0.13 μM, respectively).
期刊介绍：
Biochemical Systematics and Ecology is devoted to the publication of original papers and reviews, both submitted and invited, in two subject areas: I) the application of biochemistry to problems relating to systematic biology of organisms (biochemical systematics); II) the role of biochemistry in interactions between organisms or between an organism and its environment (biochemical ecology).
In the Biochemical Systematics subject area, comparative studies of the distribution of (secondary) metabolites within a wider taxon (e.g. genus or family) are welcome. Comparative studies, encompassing multiple accessions of each of the taxa within their distribution are particularly encouraged. Welcome are also studies combining classical chemosystematic studies (such as comparative HPLC-MS or GC-MS investigations) with (macro-) molecular phylogenetic studies. Studies that involve the comparative use of compounds to help differentiate among species such as adulterants or substitutes that illustrate the applied use of chemosystematics are welcome. In contrast, studies solely employing macromolecular phylogenetic techniques (gene sequences, RAPD studies etc.) will be considered out of scope. Discouraged are manuscripts that report known or new compounds from a single source taxon without addressing a systematic hypothesis. Also considered out of scope are studies using outdated and hard to reproduce macromolecular techniques such as RAPDs in combination with standard chemosystematic techniques such as GC-FID and GC-MS.
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