Esraa Ahmed Elmazzahy, Zahraa Ezz El Din, Marina Atef Nessem, Sarah El Tatawy
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引用次数: 0
Abstract
Background
Bilirubin neurotoxicity involves a spectrum of varying severity that could result in adverse long-term sequelae.
Aims
To compare the neurodevelopmental outcome of full-term neonates who underwent exchange transfusion with those who did not.
Study design
A retrospective cohort study.
Subjects
This study included a retrospective review of records of sixty neonates who were matched in admission ages and serum bilirubin levels and the comparison groups were those who received an exchange transfusion (n = 30) versus those where exchange transfusion was planned, but the bilirubin levels dropped sufficiently during the period where the exchange blood was being prepared (n = 30). History, clinical examination, and laboratory investigations were documented.
Outcome measures
Neurodevelopmental outcome, at 6 months of age, using Bayley scales of infant development was assessed.
Results
The exchange group had statistically significant lower cognitive scores (p-value 0.005). The higher the rate of bilirubin decline, the better the language and motor scores in the phototherapy group (p-values 0.020 and 0.024 respectively). Infants with longer duration to exchange transfusion had lower cognitive, language, and motor scores (p-values 0.01, 0.001, and 0.003 respectively).
Conclusions
Slower rates of bilirubin decline and longer duration before intervention increase the chances of adverse neurodevelopmental outcomes.
期刊介绍:
Established as an authoritative, highly cited voice on early human development, Early Human Development provides a unique opportunity for researchers and clinicians to bridge the communication gap between disciplines. Creating a forum for the productive exchange of ideas concerning early human growth and development, the journal publishes original research and clinical papers with particular emphasis on the continuum between fetal life and the perinatal period; aspects of postnatal growth influenced by early events; and the safeguarding of the quality of human survival.
The first comprehensive and interdisciplinary journal in this area of growing importance, Early Human Development offers pertinent contributions to the following subject areas:
Fetology; perinatology; pediatrics; growth and development; obstetrics; reproduction and fertility; epidemiology; behavioural sciences; nutrition and metabolism; teratology; neurology; brain biology; developmental psychology and screening.