Beyond the adverse effects of the systemic route: Exploiting nanocarriers for the topical treatment of skin cancers

IF 15.2 1区 医学 Q1 PHARMACOLOGY & PHARMACY
Beatriz da Silva Gomes , Ana Cláudia Paiva-Santos , Francisco Veiga , Filipa Mascarenhas-Melo
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Abstract

Skin cancer is a heterogeneous disease that can be divided into two main groups, melanoma and nonmelanoma skin cancers. Conventional therapies for skin cancer have numerous systemic side effects and a high recurrence rate. Topical treatment is an alternative approach, but drug permeability remains a challenge. Therefore, nanocarriers appear as important nanotechnology tools that reduces both the side effects and improves clinical outcomes. This is why they are attracting growing interest. In this review, scientific articles on the use of nanocarriers for the topical treatment of skin cancer were collected. Despite the promising results of the presented nanocarriers and considering that some of them are already on the market, there is an urgent need for investment in the development of manufacturing methods, as well as of suitable toxicological and regulatory evaluations, since the conventional methods currently used to develop these nanocarriers-based products are more time-consuming and expensive than conventional products.

Abstract Image

超越全身途径的不良影响:利用纳米载体局部治疗皮肤癌。
皮肤癌是一种异质性疾病,可分为两大类:黑色素瘤和非黑色素瘤皮肤癌。皮肤癌的传统疗法有许多全身性副作用,复发率也很高。局部治疗是一种替代方法,但药物渗透性仍然是一个难题。因此,纳米载体成为重要的纳米技术工具,既能减少副作用,又能改善临床疗效。这也是纳米载体日益受到关注的原因。本综述收集了有关使用纳米载体局部治疗皮肤癌的科学文章。尽管所介绍的纳米载体取得了可喜的成果,而且其中一些已经投放市场,但由于目前用于开发这些基于纳米载体的产品的传统方法比传统产品更耗时、更昂贵,因此迫切需要投资开发制造方法,并进行适当的毒理学和监管评估。
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来源期刊
CiteScore
28.10
自引率
5.00%
发文量
294
审稿时长
15.1 weeks
期刊介绍: The aim of the Journal is to provide a forum for the critical analysis of advanced drug and gene delivery systems and their applications in human and veterinary medicine. The Journal has a broad scope, covering the key issues for effective drug and gene delivery, from administration to site-specific delivery. In general, the Journal publishes review articles in a Theme Issue format. Each Theme Issue provides a comprehensive and critical examination of current and emerging research on the design and development of advanced drug and gene delivery systems and their application to experimental and clinical therapeutics. The goal is to illustrate the pivotal role of a multidisciplinary approach to modern drug delivery, encompassing the application of sound biological and physicochemical principles to the engineering of drug delivery systems to meet the therapeutic need at hand. Importantly the Editorial Team of ADDR asks that the authors effectively window the extensive volume of literature, pick the important contributions and explain their importance, produce a forward looking identification of the challenges facing the field and produce a Conclusions section with expert recommendations to address the issues.
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