Guinea pig herpes like virus is a gamma herpesvirus.

IF 1.9 4区医学 Q3 GENETICS & HEREDITY

Virus Genes Pub Date : 2024-04-01 Epub Date: 2024-02-10 DOI:10.1007/s11262-024-02054-x

Brent A Stanfield, Emmanuelle Ruiz, Vladimir N Chouljenko, Konstantin G Kousoulas

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Abstract

Guinea Pig Herpes-Like Virus (GPHLV) is a virus isolated from leukemic guinea pigs with herpes virus-like morphology described by Hsiung and Kaplow in 1969. GPHLV transformed embryonic cells from Syrian hamsters or rats, which were tumorigenic in adult animals. Herein, we present the genomic sequence of GPHLV strain LK40 as a reference for future molecular analysis. GPHLV has a broad host tropism and replicates efficiently in Guinea pig, Cat, and Green African Monkey-derived cell lines. GPHLV has a GC content of 35.45%. The genome is predicted to encode at least 75 open-reading frames (ORFs) with 84% (63 ORFs) sharing homology to human Kaposi Sarcoma Associated Herpes Virus (KSHV). Importantly, GPHLV encodes homologues of the KSHV oncogenes, vBCL2 (ORF16), vPK (ORF36), viral cyclin (v-cyclin, ORF72), the latency associated nuclear antigen (LANA, ORF73), and vGPCR (ORF74). GPHLV is a Rhadinovirus of Cavia porcellus, and we propose the formal name of Caviid gamma herpesvirus 1 (CaGHV-1). GPHLV can be a novel small animal model of Rhadinovirus pathogenesis with broad host tropism.

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豚鼠疱疹病毒是一种伽马疱疹病毒。

豚鼠疱疹病毒（GPHLV）是由 Hsiung 和 Kaplow 于 1969 年描述的一种从白血病豚鼠身上分离出来的具有疱疹病毒样形态的病毒。GPHLV 能转化叙利亚仓鼠或大鼠的胚胎细胞，并在成年动物体内产生肿瘤。在此，我们公布了 GPHLV 株系 LK40 的基因组序列，为今后的分子分析提供参考。GPHLV具有广泛的宿主滋养特性，可在豚鼠、猫和非洲绿猴衍生细胞系中高效复制。GPHLV 的 GC 含量为 35.45%。据预测，其基因组至少编码 75 个开放阅读框（ORF），其中 84% （63 个 ORF）与人类卡波西肉瘤相关疱疹病毒（KSHV）具有同源性。重要的是，GPHLV编码KSHV致癌基因的同源物：vBCL2（ORF16）、vPK（ORF36）、病毒细胞周期蛋白（v-cyclin，ORF72）、潜伏期相关核抗原（LANA，ORF73）和vGPCR（ORF74）。GPHLV 是一种猪豚鼠疱疹病毒，我们将其正式命名为猪豚鼠γ疱疹病毒 1（CaGHV-1）。GPHLV 是一种新型的 Rhadinovirus 致病小动物模型，具有广泛的宿主滋养特性。

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来源期刊

Virus Genes 医学-病毒学

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： Viruses are convenient models for the elucidation of life processes. The study of viruses is again on the cutting edge of biological sciences: systems biology, genomics, proteomics, metagenomics, using the newest most powerful tools. Huge amounts of new details on virus interactions with the cell, other pathogens and the hosts – animal (including human), insect, fungal, plant, bacterial, and archaeal - and their role in infection and disease are forthcoming in perplexing details requiring analysis and comments. Virus Genes is dedicated to the publication of studies on the structure and function of viruses and their genes, the molecular and systems interactions with the host and all applications derived thereof, providing a forum for the analysis of data and discussion of its implications, and the development of new hypotheses.