Pediatric patients diagnosed as overweight and obese have an elevated risk of dyspnea

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-02-09 DOI:10.1016/j.resp.2024.104230

Lydia S. Robson , Abidan Abulimiti , Jorge Z. Granados , Ayesha N. Zia , Bryce N. Balmain , James A. Pawelczyk , Tony G. Babb

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Abstract

We investigated whether pediatric patients with overweight and obesity are more likely to have dyspnea compared with those who are non-overweight. We collected de-identified data from TriNetX, a global federated multicenter research database, using both the UT Southwestern Medical Center and multinational Research Networks. Our analysis focused on patients aged 8–12 years. We identified overweight and obesity using ICD-10-CM codes E66 and dyspnea using code R06.0. Patients with overweight and obesity had a significantly higher risk of dyspnea compared with those who were non-overweight. This association was observed in both the UT Southwestern Network (risk ratio: 1.81, p < 0.001) and the Research Network (risk ratio: 2.70, p < 0.001). Furthermore, within the UT Southwestern Network, the risk was found to be higher in females compared with males (risk ratio: 2.17 vs. 1.67). These results have significant clinical implications, suggesting that clinicians should consider overweight and obesity as independent risk factors for dyspnea in pediatric patients after excluding other possible contributing factors.

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被诊断为超重和肥胖的儿科患者出现呼吸困难的风险较高。

我们研究了超重和肥胖的儿科患者与非超重患者相比是否更容易出现呼吸困难。我们通过UT西南医学中心和跨国研究网络从全球联合多中心研究数据库TriNetX收集了去标识化数据。我们的分析侧重于 8-12 岁的患者。我们使用 ICD-10-CM 代码 E66 识别超重和肥胖，使用代码 R06.0 识别呼吸困难。与非超重患者相比，超重和肥胖患者出现呼吸困难的风险明显更高。这种关联在UT Southwestern网络中均可观察到（风险比：1.81，P＜0.05）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.