The role of glutamic acid-modified silica nanoparticles in promoting brain health

Abstract

SiO₂ nanoparticles functionalized with glutamate were investigated for their ability to alleviate oxidative stress caused by prolonged exposure to hydrogen peroxide (H₂O₂). The study involved ten different groups, each consisting of eight animals, to examine the effects of H₂O₂ -induced oxidative stress. The results demonstrated that exposure to H₂O₂ stress oxidative biomarkers were altered accompanied with a loss of spatial learning and memory in rats performing the Morris water maze task. Furthermore, SiO₂ nanoparticles functionalized with L-glutamic acid alleviated the H₂O₂-induced acceleration of necrotic and degenerative cell changes in the hippocampus, subiculum, caudate-putamen, and frontal cortex. Additionally, L-glutamic acid-functionalized SiO₂ nanoparticles reduced the redox imbalance and interfered with acetylcholinesterase (AChE) and monoamine oxidase (MAO) activities induced by H₂O₂.