Hypoxia inducible factor-1α related mechanism and TCM intervention in process of early fracture healing

IF 4.7 4区 医学 Q1 CHEMISTRY, MEDICINAL
Wenxian Zhang , Fusen Yang , Qikai Yan , Jiahui Li , Xiaogang Zhang , Yiwei Jiang , Jianye Dai
{"title":"Hypoxia inducible factor-1α related mechanism and TCM intervention in process of early fracture healing","authors":"Wenxian Zhang ,&nbsp;Fusen Yang ,&nbsp;Qikai Yan ,&nbsp;Jiahui Li ,&nbsp;Xiaogang Zhang ,&nbsp;Yiwei Jiang ,&nbsp;Jianye Dai","doi":"10.1016/j.chmed.2023.09.006","DOIUrl":null,"url":null,"abstract":"<div><p>As a common clinical disease, fracture is often accompanied by pain, swelling, bleeding as well as other symptoms and has a high disability rate, even threatening life, seriously endangering patients’ physical and psychological health and quality of life. Medical practitioners take many strategies for the treatment of fracture healing, including Traditional Chinese Medicine (TCM). In the early stage of fracture healing, the local fracture is often in a state of hypoxia, accompanied by the expression of hypoxia inducible factor-1α (HIF-1α), which is beneficial to wound healing. Through literature mining, we thought that hypoxia, HIF-1α and downstream factors affected the mechanism of fracture healing, as well as dominated this process. Therefore, we reviewed the local characteristics and related signaling pathways involved in the fracture healing process and summarized the intervention of TCM on these mechanisms, in order to inspirit the new strategy for fracture healing, as well as elaborate on the possible principles of TCM in treating fractures based on the HIF molecular mechanism.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":null,"pages":null},"PeriodicalIF":4.7000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638423001090/pdfft?md5=a96bbfc2243d898f365d9f56fad6f10f&pid=1-s2.0-S1674638423001090-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chinese Herbal Medicines","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1674638423001090","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0

Abstract

As a common clinical disease, fracture is often accompanied by pain, swelling, bleeding as well as other symptoms and has a high disability rate, even threatening life, seriously endangering patients’ physical and psychological health and quality of life. Medical practitioners take many strategies for the treatment of fracture healing, including Traditional Chinese Medicine (TCM). In the early stage of fracture healing, the local fracture is often in a state of hypoxia, accompanied by the expression of hypoxia inducible factor-1α (HIF-1α), which is beneficial to wound healing. Through literature mining, we thought that hypoxia, HIF-1α and downstream factors affected the mechanism of fracture healing, as well as dominated this process. Therefore, we reviewed the local characteristics and related signaling pathways involved in the fracture healing process and summarized the intervention of TCM on these mechanisms, in order to inspirit the new strategy for fracture healing, as well as elaborate on the possible principles of TCM in treating fractures based on the HIF molecular mechanism.

缺氧诱导因子-1α在骨折早期愈合过程中的相关机制与中医干预
骨折是临床常见疾病,常伴有疼痛、肿胀、出血等症状,致残率高,甚至危及生命,严重危害患者的身心健康和生活质量。对于骨折愈合的治疗,医学家们采取了多种策略,其中包括中医疗法。在骨折愈合早期,骨折局部往往处于缺氧状态,同时伴有有利于伤口愈合的缺氧诱导因子-1α(HIF-1α)的表达。通过文献挖掘,我们认为缺氧、HIF-1α及下游因子影响骨折愈合的机制,并主导这一过程。因此,我们回顾了骨折愈合过程中的局部特征和相关信号通路,总结了中医药对这些机制的干预,以启发骨折愈合的新策略,并阐述了基于HIF分子机制的中医药治疗骨折的可能原则。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Chinese Herbal Medicines
Chinese Herbal Medicines CHEMISTRY, MEDICINAL-
CiteScore
4.40
自引率
5.30%
发文量
629
审稿时长
10 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信