Pathological causes of sudden death in autopsied children with reference to peculiar findings: An Egyptian perspective

IF 1.2 4区 医学 Q3 MEDICINE, LEGAL
Nora Fawzy Fnon , Nour El-Hoda Sayed Ismael , Hanan Hosney Hassan , Samar Abd-Elmonem El-Sheikh , Zahraa Khalifa Sobh
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Abstract

Childhood is a long period extending up to the age of 18 years. Childhood encompasses different developmental stages; each stage has specific characteristics. This 5-year study included 244 autopsied children who died unexpectedly due to natural causes. This study was conducted in the forensic pathology unit of the Egyptian Forensic Medicine Authority (EFMA). Pathological causes of death were diagnosed in 181 cases, representing nearly three-quarters (74.2 %) of cases. Males represented 60.8 % of these cases. More than half (51.4 %) of deaths due to natural disease occurred within the first month of life. The diagnosis was established for the first-time during autopsy in 58 % of cases. Prematurity complications and infections were the cause of death in 35.9 % and 30.4 % of deaths attributed to natural pathologies, respectively. Prematurity complications are the most common cause of death in perinatal (63.6) and neonatal (71.4 %) periods. Whereas infection is the most common cause of death during infancy (55 %), childhood (52.8 %), and adolescence (43.8 %). Pneumonia was the most common infection (61.8 %). This study highlighted cases with peculiar pathologies that include cardiomyopathies (idiopathic dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM), and Arrhythmogenic right ventricular cardiomyopathy (ARVD)), Waterhouse-Friderichsen syndrome (WFS), ruptured cerebral cavernous hemangioma, and cerebellar medulloblastoma.

尸检儿童猝死的病理原因及特殊发现:埃及视角
童年是一个漫长的时期,一直延续到 18 岁。童年包括不同的发育阶段;每个阶段都有特定的特征。这项为期 5 年的研究包括 244 名因自然原因意外死亡的尸检儿童。这项研究是在埃及法医管理局(EFMA)的法医病理学部门进行的。181例病理死亡病因得到诊断,占近四分之三(74.2%)的病例。其中男性占 60.8%。一半以上(51.4%)的自然死亡病例发生在婴儿出生后的第一个月内。58%的病例是在尸检时首次确诊的。早产并发症和感染分别是35.9%和30.4%自然病理死亡的原因。早产并发症是围产期(63.6%)和新生儿期(71.4%)最常见的死因。而感染是婴儿期(55%)、儿童期(52.8%)和青少年期(43.8%)最常见的死因。肺炎是最常见的感染(61.8%)。本研究强调了具有特殊病理特征的病例,包括心肌病(特发性扩张型心肌病(DCM)、肥厚型心肌病(HCM)和致心律失常性右室心肌病(ARVD))、沃特豪斯-弗里德里希森综合征(WFS)、脑海绵状血管瘤破裂和小脑髓母细胞瘤。
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来源期刊
CiteScore
2.70
自引率
6.70%
发文量
106
审稿时长
57 days
期刊介绍: The Journal of Forensic and Legal Medicine publishes topical articles on aspects of forensic and legal medicine. Specifically the Journal supports research that explores the medical principles of care and forensic assessment of individuals, whether adult or child, in contact with the judicial system. It is a fully peer-review hybrid journal with a broad international perspective. The Journal accepts submissions of original research, review articles, and pertinent case studies, editorials, and commentaries in relevant areas of Forensic and Legal Medicine, Context of Practice, and Education and Training. The Journal adheres to strict publication ethical guidelines, and actively supports a culture of inclusive and representative publication.
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