Zeshi SUN , Shan LIN , Zhi-Li WU , Hong-Yuan DONG , Xi-Ke XU , Hui-Liang LI , Jinxin WANG
{"title":"New phenylbutenoids and terpene glycosides from Ginkgo biloba leaves","authors":"Zeshi SUN , Shan LIN , Zhi-Li WU , Hong-Yuan DONG , Xi-Ke XU , Hui-Liang LI , Jinxin WANG","doi":"10.1016/S1875-5364(24)60588-1","DOIUrl":null,"url":null,"abstract":"<div><p>Our continued works on the chemical constituents of <em>Ginkgo biloba</em> (<em>G. biloba</em>) leaves has led to the isolation of two novel phenylbutenoids (<strong>1, 2</strong>), along with five previously unidentified terpene glycosides (<strong>3–7</strong>). Among them, compounds <strong>1</strong> and <strong>2</strong> represent unique (<em>Z</em>)-phenylbutenoids, <strong>3–6</strong> are megastigmane glycosides, and <strong>7</strong> is identified as a rare bilobanone glycoside (Fig. 1). This study marks the first reported isolation of phenylbutenoid and bilobanone glycoside from <em>G. biloba</em>. The chemical structures of these compounds were elucidated through extensive spectroscopic analysis, including HR-ESI-MS and various 1D and 2D NMR experiments. Furthermore, the absolute configurations of these molecules were determined using Mosher's method, ECD experiments, and Cu-Kα X-ray crystallographic analyses.</p></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"22 2","pages":"Pages 161-170"},"PeriodicalIF":4.0000,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chinese Journal of Natural Medicines","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1875536424605881","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INTEGRATIVE & COMPLEMENTARY MEDICINE","Score":null,"Total":0}
引用次数: 0
Abstract
Our continued works on the chemical constituents of Ginkgo biloba (G. biloba) leaves has led to the isolation of two novel phenylbutenoids (1, 2), along with five previously unidentified terpene glycosides (3–7). Among them, compounds 1 and 2 represent unique (Z)-phenylbutenoids, 3–6 are megastigmane glycosides, and 7 is identified as a rare bilobanone glycoside (Fig. 1). This study marks the first reported isolation of phenylbutenoid and bilobanone glycoside from G. biloba. The chemical structures of these compounds were elucidated through extensive spectroscopic analysis, including HR-ESI-MS and various 1D and 2D NMR experiments. Furthermore, the absolute configurations of these molecules were determined using Mosher's method, ECD experiments, and Cu-Kα X-ray crystallographic analyses.
期刊介绍：
The Chinese Journal of Natural Medicines (CJNM), founded and sponsored in May 2003 by China Pharmaceutical University and the Chinese Pharmaceutical Association, is devoted to communication among pharmaceutical and medical scientists interested in the advancement of Traditional Chinese Medicines (TCM). CJNM publishes articles relating to a broad spectrum of bioactive natural products, leading compounds and medicines derived from Traditional Chinese Medicines (TCM).
Topics covered by the journal are: Resources of Traditional Chinese Medicines; Interaction and complexity of prescription; Natural Products Chemistry (including structure modification, semi-and total synthesis, bio-transformation); Pharmacology of natural products and prescription (including pharmacokinetics and toxicology); Pharmaceutics and Analytical Methods of natural products.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
