Interorgan rhythmicity as a feature of healthful metabolism.

Cell metabolism Pub Date : 2024-04-02 Epub Date: 2024-02-08 DOI:10.1016/j.cmet.2024.01.009
Joseph Bass
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Abstract

The finding that animals with circadian gene mutations exhibit diet-induced obesity and metabolic syndrome with hypoinsulinemia revealed a distinct role for the clock in the brain and peripheral tissues. Obesogenic diets disrupt rhythmic sleep/wake patterns, feeding behavior, and transcriptional networks, showing that metabolic signals reciprocally control the clock. Providing access to high-fat diet only during the sleep phase (light period) in mice accelerates weight gain, whereas isocaloric time-restricted feeding during the active period enhances energy expenditure due to circadian induction of adipose thermogenesis. This perspective focuses on advances and unanswered questions in understanding the interorgan circadian control of healthful metabolism.

器官间节律性是健康新陈代谢的一个特征。
昼夜节律基因突变的动物表现出饮食诱发的肥胖和代谢综合征,并伴有低胰岛素血症,这一发现揭示了时钟在大脑和外周组织中的独特作用。肥胖饮食会扰乱有节律的睡眠/觉醒模式、进食行为和转录网络,这表明代谢信号会相互控制时钟。仅在小鼠睡眠期(光照期)提供高脂肪饮食会加速体重增加,而在活动期进行等热量限时喂养则会因昼夜节律诱导脂肪产热而增加能量消耗。本视角重点关注在了解健康代谢的器官间昼夜节律控制方面的进展和未解之谜。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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