Effect of intra-articular platelet-rich plasma or hyaluronic acid on limb function recovery in dogs with TPLO for cranial cruciate ligament rupture: a randomised controlled trial

IF 1.7 2区农林科学 Q2 VETERINARY SCIENCES

Journal of Small Animal Practice Pub Date : 2024-02-10 DOI:10.1111/jsap.13704

F. Volz, D. Eberle, M. Kornmayer, Y. Zablotski, A. Meyer-Lindenberg

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引用次数: 0

Abstract

Objectives

This study aimed to investigate the recovery of limb function following a single intra-articular injection of platelet-rich plasma or hyaluronic acid in dogs with cranial cruciate ligament rupture treated with tibial plateau levelling osteotomy compared to dogs receiving no injection intraoperatively.

Materials and Methods

Sixty-two dogs with cranial cruciate ligament rupture, body weights of 20 to 40 kg, and no other orthopaedic conditions were enrolled in this prospective, randomised, double-blind, controlled study at the small animal clinic at LMU Munich. All dogs underwent tibial plateau levelling osteotomy. Based on random allocation, they received either a single intra-articular injection of platelet-rich plasma, hyaluronic acid or no injection intraoperatively. Gait analysis, clinical examinations, radiography of the stifle joint for osteoarthritis progression and two validated owner questionnaires were compared among groups at three timepoints postoperatively (6 weeks, 3 and 6 months). Limb function was primarily assessed by measuring the ground reaction forces.

Results

At all times postoperatively, no differences were observed among groups regarding clinical examinations, osteoarthritis score values, ground reaction forces or owner questionnaires. All dogs showed significant improvement in limb function clinically, in all ground reaction forces and in the validated questionnaires. Osteoarthritis progressed minimally during rechecks in all dogs regardless of the additional injection or not.

Clinical Significance

All dogs treated with tibial plateau levelling osteotomy for cranial cruciate ligament rupture showed improvements in limb function. No additive effect on faster recovery was demonstrated with the additional intra-articular injection of platelet-rich plasma or hyaluronic acid. Addition of platelet-rich plasma/hyaluronic acid injections during tibial plateau levelling osteotomy is unnecessary considering the lack of benefit observed up to 6 months postoperatively.

查看原文本刊更多论文

关节内富血小板血浆或透明质酸对颅骨十字韧带断裂 TPLO 犬肢体功能恢复的影响：随机对照试验。

研究目的本研究旨在调查在胫骨平台平整截骨术治疗颅十字韧带断裂的犬只关节内注射一次富血小板血浆或透明质酸后肢体功能的恢复情况，并与术中未注射的犬只进行比较：这项前瞻性、随机、双盲、对照研究招募了 62 只患有颅十字韧带断裂、体重在 20 至 40 千克之间、无其他骨科疾病的狗，这些狗在慕尼黑 LMU 小动物诊所接受治疗。所有狗都接受了胫骨平台平整截骨术。根据随机分配，它们在术中接受了一次富血小板血浆、透明质酸或无注射的关节内注射。在术后三个时间点（6 周、3 个月和 6 个月），对各组的步态分析、临床检查、跗关节骨关节炎进展的 X 射线检查和两份经过验证的所有者问卷进行比较。肢体功能主要通过测量地面反作用力进行评估：结果：在术后的所有时间点，各组在临床检查、骨关节炎评分值、地面反作用力或狗主人问卷调查方面均未发现差异。所有狗的临床肢体功能、所有地面反作用力和有效问卷均有明显改善。在复查期间，无论是否额外注射，所有犬的骨关节炎进展都很小：临床意义：所有接受胫骨平台平整截骨术治疗头颅十字韧带断裂的狗的肢体功能都有所改善。在关节内额外注射富血小板血浆或透明质酸对加快恢复速度没有额外效果。考虑到在术后 6 个月内未观察到任何益处，在胫骨平台平整截骨术中增加注射富血小板血浆/透明质酸是不必要的。

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来源期刊

Journal of Small Animal Practice 农林科学-兽医学

CiteScore

3.30

自引率

6.20%

发文量

117

审稿时长

12-24 weeks

期刊介绍： Journal of Small Animal Practice (JSAP) is a monthly peer-reviewed publication integrating clinical research papers and case reports from international sources, covering all aspects of medicine and surgery relating to dogs, cats and other small animals. These papers facilitate the dissemination and implementation of new ideas and techniques relating to clinical veterinary practice, with the ultimate aim of promoting best practice. JSAP publishes high quality original articles, as well as other scientific and educational information. New developments are placed in perspective, encompassing new concepts and peer commentary. The target audience is veterinarians primarily engaged in the practise of small animal medicine and surgery. In addition to original articles, JSAP will publish invited editorials (relating to a manuscript in the same issue or a topic of current interest), review articles, which provide in-depth discussion of important clinical issues, and other scientific and educational information from around the world. The final decision on publication of a manuscript rests with the Editorial Board and ultimately with the Editor. All papers, regardless of type, represent the opinion of the authors and not necessarily that of the Editor, the Association or the Publisher. The Journal of Small Animal Practice is published on behalf of the British Small Animal Veterinary Association and is also the official scientific journal of the World Small Animal Veterinary Association