Intestinal metabolites predict treatment resistance of patients with depression and anxiety.

IF 4.3 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Gut Pathogens Pub Date : 2024-02-09 DOI:10.1186/s13099-024-00601-3

Juntaro Matsuzaki, Shunya Kurokawa, Chiaki Iwamoto, Katsuma Miyaho, Akihiro Takamiya, Chiharu Ishii, Akiyoshi Hirayama, Kenji Sanada, Shinji Fukuda, Masaru Mimura, Taishiro Kishimoto, Yoshimasa Saito

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引用次数: 0

Abstract

Background: The impact of the gut microbiota on neuropsychiatric disorders has gained much attention in recent years; however, comprehensive data on the relationship between the gut microbiome and its metabolites and resistance to treatment for depression and anxiety is lacking. Here, we investigated intestinal metabolites in patients with depression and anxiety disorders, and their possible roles in treatment resistance.

Results: We analyzed fecal metabolites and microbiomes in 34 participants with depression and anxiety disorders. Fecal samples were obtained three times for each participant during the treatment. Propensity score matching led us to analyze data from nine treatment responders and nine non-responders, and the results were validated in the residual sample sets. Using elastic net regression analysis, we identified several metabolites, including N-ε-acetyllysine; baseline levels of the former were low in responders (AUC = 0.86; 95% confidence interval, 0.69-1). In addition, fecal levels of N-ε-acetyllysine were negatively associated with the abundance of Odoribacter. N-ε-acetyllysine levels increased as symptoms improved with treatment.

Conclusion: Fecal N-ε-acetyllysine levels before treatment may be a predictive biomarker of treatment-refractory depression and anxiety. Odoribacter may play a role in the homeostasis of intestinal L-lysine levels. More attention should be paid to the importance of L-lysine metabolism in those with depression and anxiety.

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肠道代谢物可预测抑郁症和焦虑症患者的耐药性。

背景：近年来，肠道微生物群对神经精神疾病的影响备受关注；然而，关于肠道微生物群及其代谢物与抑郁症和焦虑症治疗耐受性之间关系的全面数据还很缺乏。在此，我们研究了抑郁症和焦虑症患者的肠道代谢物及其在治疗耐药性中可能扮演的角色：我们分析了 34 名抑郁症和焦虑症患者的粪便代谢物和微生物组。每位患者在治疗期间均采集了三次粪便样本。通过倾向得分匹配，我们分析了九名治疗应答者和九名非应答者的数据，并在剩余样本集中验证了结果。通过弹性净回归分析，我们确定了几种代谢物，包括 N-ε-乙酰赖氨酸；前者在应答者中的基线水平较低（AUC = 0.86；95% 置信区间，0.69-1）。此外，粪便中的 N-ε-乙酰赖氨酸水平与臭味菌的数量呈负相关。N-ε-乙酰赖氨酸水平随着治疗后症状的改善而增加：结论：治疗前的粪便N-ε-乙酰赖氨酸水平可能是难治性抑郁症和焦虑症的预测性生物标志物。厌氧菌可能在肠道 L-赖氨酸水平的平衡中发挥作用。应更加关注 L-赖氨酸代谢对抑郁症和焦虑症患者的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gut Pathogens GASTROENTEROLOGY & HEPATOLOGY-MICROBIOLOGY

CiteScore

7.70

自引率

2.40%

发文量

期刊介绍： Gut Pathogens is a fast publishing, inclusive and prominent international journal which recognizes the need for a publishing platform uniquely tailored to reflect the full breadth of research in the biology and medicine of pathogens, commensals and functional microbiota of the gut. The journal publishes basic, clinical and cutting-edge research on all aspects of the above mentioned organisms including probiotic bacteria and yeasts and their products. The scope also covers the related ecology, molecular genetics, physiology and epidemiology of these microbes. The journal actively invites timely reports on the novel aspects of genomics, metagenomics, microbiota profiling and systems biology. Gut Pathogens will also consider, at the discretion of the editors, descriptive studies identifying a new genome sequence of a gut microbe or a series of related microbes (such as those obtained from new hosts, niches, settings, outbreaks and epidemics) and those obtained from single or multiple hosts at one or different time points (chronological evolution).