Revealing the clinical potential of high-resolution organoids

IF 15.2 1区 医学 Q1 PHARMACOLOGY & PHARMACY
Jihoon Ko , Sujin Hyung , Sunghun Cheong , Yoojin Chung , Noo Li Jeon
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引用次数: 0

Abstract

The symbiotic interplay of organoid technology and advanced imaging strategies yields innovative breakthroughs in research and clinical applications. Organoids, intricate three-dimensional cell cultures derived from pluripotent or adult stem/progenitor cells, have emerged as potent tools for in vitro modeling, reflecting in vivo organs and advancing our grasp of tissue physiology and disease. Concurrently, advanced imaging technologies such as confocal, light-sheet, and two-photon microscopy ignite fresh explorations, uncovering rich organoid information. Combined with advanced imaging technologies and the power of artificial intelligence, organoids provide new insights that bridge experimental models and real-world clinical scenarios. This review explores exemplary research that embodies this technological synergy and how organoids reshape personalized medicine and therapeutics.

Abstract Image

揭示高分辨率有机体的临床潜力
类器官技术和先进成像策略的共生相互作用,为研究和临床应用带来了创新性突破。类器官是由多能或成体干细胞/祖细胞衍生的复杂的三维细胞培养物,已成为体外建模的有力工具,可反映体内器官,促进我们对组织生理学和疾病的掌握。与此同时,共焦、光片和双光子显微镜等先进成像技术点燃了新的探索,揭示了丰富的类器官信息。结合先进的成像技术和人工智能的力量,类器官提供了连接实验模型和真实世界临床场景的新见解。这篇综述探讨了体现这种技术协同作用的典范研究,以及类器官如何重塑个性化医学和疗法。
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来源期刊
CiteScore
28.10
自引率
5.00%
发文量
294
审稿时长
15.1 weeks
期刊介绍: The aim of the Journal is to provide a forum for the critical analysis of advanced drug and gene delivery systems and their applications in human and veterinary medicine. The Journal has a broad scope, covering the key issues for effective drug and gene delivery, from administration to site-specific delivery. In general, the Journal publishes review articles in a Theme Issue format. Each Theme Issue provides a comprehensive and critical examination of current and emerging research on the design and development of advanced drug and gene delivery systems and their application to experimental and clinical therapeutics. The goal is to illustrate the pivotal role of a multidisciplinary approach to modern drug delivery, encompassing the application of sound biological and physicochemical principles to the engineering of drug delivery systems to meet the therapeutic need at hand. Importantly the Editorial Team of ADDR asks that the authors effectively window the extensive volume of literature, pick the important contributions and explain their importance, produce a forward looking identification of the challenges facing the field and produce a Conclusions section with expert recommendations to address the issues.
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