Intranasal drug delivery: The interaction between nanoparticles and the nose-to-brain pathway

IF 15.2 1区医学 Q1 PHARMACOLOGY & PHARMACY

Advanced drug delivery reviews Pub Date : 2024-02-07 DOI:10.1016/j.addr.2024.115196

Yaoxing Chen , Chenyun Zhang , Yukun Huang , Yuxiao Ma , Qingxiang Song , Hongzhuan Chen , Gan Jiang , Xiaoling Gao

引用次数: 0

Abstract

Intranasal delivery provides a direct and non-invasive method for drugs to reach the central nervous system. Nanoparticles play a crucial role as carriers in augmenting the efficacy of brain delivery. However, the interaction between nanoparticles and the nose-to-brain pathway and how the various biopharmaceutical factors affect brain delivery efficacy remains unclear. In this review, we comprehensively summarized the anatomical and physiological characteristics of the nose-to-brain pathway and the obstacles that hinder brain delivery. We then outlined the interaction between nanoparticles and this pathway and reviewed the biomedical applications of various nanoparticulate drug delivery systems for nose-to-brain drug delivery. This review aims at inspiring innovative approaches for enhancing the effectiveness of nose-to-brain drug delivery in the treatment of different brain disorders.

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鼻内给药：纳米颗粒与鼻脑通路之间的相互作用。

我们概述了鼻脑通路的解剖学和生理学以及相关机制。然后，我们总结了纳米颗粒与这一途径的相互作用过程，以及从天然纳米物质中获得的潜在策略。这篇综述可能有助于激发鼻内给药在治疗各种脑部疾病方面的应用潜力。鼻内给药为药物到达中枢神经系统提供了一种直接、非侵入性的方法。纳米颗粒作为载体，在提高脑部给药疗效方面发挥着至关重要的作用。然而，纳米颗粒与鼻脑通路之间的相互作用以及各种生物制药因素如何影响脑部给药疗效仍不清楚。在这篇综述中，我们全面总结了鼻脑通路的解剖和生理特点以及阻碍脑部给药的障碍。然后，我们概述了纳米颗粒与这一途径之间的相互作用，并回顾了各种纳米颗粒给药系统在鼻脑给药方面的生物医学应用。本综述旨在启发创新方法，提高鼻脑给药在治疗不同脑部疾病方面的有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced drug delivery reviews 医学-药学

CiteScore

28.10

自引率

5.00%

发文量

294

审稿时长

15.1 weeks

期刊介绍： The aim of the Journal is to provide a forum for the critical analysis of advanced drug and gene delivery systems and their applications in human and veterinary medicine. The Journal has a broad scope, covering the key issues for effective drug and gene delivery, from administration to site-specific delivery. In general, the Journal publishes review articles in a Theme Issue format. Each Theme Issue provides a comprehensive and critical examination of current and emerging research on the design and development of advanced drug and gene delivery systems and their application to experimental and clinical therapeutics. The goal is to illustrate the pivotal role of a multidisciplinary approach to modern drug delivery, encompassing the application of sound biological and physicochemical principles to the engineering of drug delivery systems to meet the therapeutic need at hand. Importantly the Editorial Team of ADDR asks that the authors effectively window the extensive volume of literature, pick the important contributions and explain their importance, produce a forward looking identification of the challenges facing the field and produce a Conclusions section with expert recommendations to address the issues.