Relationship between Vaginal Bacterial Infections and Pregnancy Outcomes: A Systematic Review and Meta-Analysis.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-01-09 eCollection Date: 2024-01-01 DOI:10.4103/ijnmr.ijnmr_199_22

Hojjat Rokni, Amjad Ahmadi, Yousef Moradi, Bijan Nouri, Daem Roshani

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引用次数: 0

Abstract

Background: Bacterial infections are among the most serious infections worldwide. They can cause miscarriage, premature birth, stillbirth, and ectopic pregnancy in pregnant women. The aim of this study was to investigate the relationship between bacterial infections and pregnancy outcomes through a systematic review and meta-analysis.

Materials and methods: PubMed, Scopus, Web of Science, and Embase databases were searched from January 2000 to December 2018 using appropriate keywords to identify related articles. The final related studies were selected and evaluated using the Newcastle-Ottawa Scale (NOS).

Results: Results of this meta-analysis based on combining case-control studies showed that the presence of bacterial infections could lead increase in the odds of all pregnancy outcomes like premature infant birth (odd ratio [OR]: 1.50; 95% Confidence Interval [CI], 1.39-1.61), preterm delivery (OR: 1.54; 95% CI, 1.39-1.70), abortion (OR: 1.16; 95% CI, 1.04-1.29), stillbirth (OR, 1.29; 95% CI, 1.12-1.49), and ectopic pregnancy (OR: 1.12; 95% CI, 1.05--1.19). The results showed that the Risk Ratio (RR) of preterm delivery in pregnant women with vaginal infections was 1.57 (95% CI, 1.46-1.67), whereas the RR of abortion was 2.02 (95% CI, 1.72-2.38).

Conclusions: Based on the results of this meta-analysis, the presence of bacterial infections in pregnant women can lead increase in the risk of pregnancy outcomes especially, preterm delivery, abortion, stillbirth, and ectopic pregnancy. Therefore, it is necessary for obstetricians and gynecologists to pay attention to the diagnosis of these infections in women before pregnancy and during pregnancy in order to prevent the consequences of these infections.

查看原文本刊更多论文

阴道细菌感染与妊娠结局之间的关系：系统回顾与元分析》。

背景：细菌感染是全球最严重的感染之一。细菌感染可导致孕妇流产、早产、死胎和宫外孕。本研究旨在通过系统综述和荟萃分析，探讨细菌感染与妊娠结局之间的关系：使用适当的关键词检索了 2000 年 1 月至 2018 年 12 月期间的 PubMed、Scopus、Web of Science 和 Embase 数据库，以确定相关文章。采用纽卡斯尔-渥太华量表（Newcastle-Ottawa Scale，NOS）对最终的相关研究进行筛选和评估：这项基于病例对照研究的荟萃分析结果表明，细菌感染的存在会导致婴儿早产等所有妊娠结局的几率增加（奇数比[OR]：1.50；95% 置信区间 [CI]，1.39-1.61）、早产（OR：1.54；95% CI，1.39-1.70）、流产（OR：1.16；95% CI，1.04-1.29）、死胎（OR，1.29；95% CI，1.12-1.49）和宫外孕（OR：1.12；95% CI，1.05--1.19）。结果显示，阴道感染孕妇早产的风险比（RR）为 1.57（95% CI，1.46-1.67），而流产的风险比为 2.02（95% CI，1.72-2.38）：根据这项荟萃分析的结果，孕妇出现细菌感染会增加妊娠结局的风险，尤其是早产、流产、死胎和宫外孕。因此，妇产科医生有必要在妇女怀孕前和怀孕期间注意这些感染的诊断，以预防这些感染的后果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.