Processing speed in first episode of psychosis and first-degree relatives: A candidate endophenotype of spectrum schizophrenia disorders.

IF 2.6 3区心理学 Q3 NEUROSCIENCES

Neuropsychology Pub Date : 2024-05-01 Epub Date: 2024-02-08 DOI:10.1037/neu0000931

Ángel Yorca-Ruiz, Nancy Murillo-García, Rebeca Magdaleno Herrero, Alexandre Díaz-Pons, Víctor Ortiz García de la Foz, Luis Manuel Fernández Cacho, Mónica L Fanarraga, Rosa Ayesa-Arriola

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引用次数: 0

Abstract

Objective: The processing speed (PS) is highly impacted in individuals experiencing their first episode of psychosis (FEP). Conducting family studies can help to determine whether PS can serve as an endophenotype of schizophrenia spectrum disorders (SSDs), offering valuable insights into the prevention and diagnosis of SSDs.

Method: A comprehensive cognitive battery, encompassing tests for PS, verbal memory, visual memory, working memory, executive functions, motor dexterity, and attention, was administered to a sample consisting of 133 FEP patients, 146 parents, 98 siblings, and 202 healthy controls (HCs). Univariate analyses (analysis of covariance [ANCOVA]) were conducted to compare the different cognitive domains between groups, utilizing sex, age, and years of education as covariates and Bonferroni corrections. Effect sizes (ESs) were calculated for estimating the magnitude of differences between groups.

Results: Group comparisons revealed significant differences in all cognitive domains. PS was the most impaired function in patients. Parents and siblings had intermediate PS performance between FEP patients and HC. Large ES were observed in PS between FEP versus siblings, FEP versus controls, parents versus controls, and parents versus siblings.

Conclusions: Despite not meeting all the necessary criteria, the PS observed in FEP patients and their first-degree relatives suggests its potential as a promising endophenotype of SSDs. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

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首次发作的精神病患者和一级亲属的处理速度：精神分裂症谱系障碍的候选内表型

目的：首次精神病发作（FEP）患者的处理速度（PS）会受到很大影响。开展家族研究有助于确定处理速度是否可以作为精神分裂症谱系障碍（SSD）的内表型，从而为精神分裂症谱系障碍的预防和诊断提供有价值的见解：方法：对 133 名 FEP 患者、146 名父母、98 名兄弟姐妹和 202 名健康对照者（HCs）进行了全面的认知测试，包括 PS、言语记忆、视觉记忆、工作记忆、执行功能、运动灵活性和注意力测试。采用单变量分析（协方差分析 [ANCOVA]）对不同组间的认知领域进行比较，将性别、年龄和受教育年限作为协变量，并进行 Bonferroni 校正。计算效应大小（ES）以估计组间差异的程度：结果表明：组间比较显示出所有认知领域的显著差异。PS 是患者受损最严重的功能。父母和兄弟姐妹在 PS 方面的表现介于 FEP 患者和 HC 之间。FEP患者与兄弟姐妹、FEP患者与对照组、父母与对照组以及父母与兄弟姐妹之间在PS方面存在较大的ES：结论：尽管不符合所有必要的标准，但在 FEP 患者及其一级亲属中观察到的 PS 表明，它有可能成为一种有前途的 SSD 内表型。(PsycInfo Database Record (c) 2024 APA，版权所有）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropsychology 医学-神经科学

CiteScore

4.10

自引率

4.20%

发文量

132

审稿时长

6-12 weeks

期刊介绍： Neuropsychology publishes original, empirical research; systematic reviews and meta-analyses; and theoretical articles on the relation between brain and human cognitive, emotional, and behavioral function.