Morin ameliorates myocardial injury in diabetic rats via modulation of inflammatory pathways.

IF 2.7 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Laboratory Animal Research Pub Date : 2024-02-09 DOI:10.1186/s42826-024-00190-x

Vipin Kumar Verma, Salma Malik, Ekta Mutneja, Anil Kumar Sahu, Vaishali Prajapati, Prashant Mishra, Jagriti Bhatia, Dharamveer Singh Arya

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Abstract

Background: High blood glucose levels in diabetes lead to vascular inflammation which accelerates atherosclerosis. Herein, Morin was orally administered in male Wistar rats, at the dose of 40 mg/kg for 28 days, and on the 27th and 28th day, ISO was administered to designate groups at the dose of 85 mg/kg s.c., to induce myocardial infarction.

Results: Free radical generation, including ROS, in diabetes following ISO administration, leads to the activation of both intrinsic and extrinsic pathways of apoptosis. Morin significantly (p ≤ 0.05) reduced oxidative stress (GSH, MDA, SOD), cardiac injury markers (CK-MB, LDH), inflammation (TNF, IL-6), and apoptosis (Bax, BCl₂, Caspase-3). In addition, it also reduced insulin and blood glucose levels. Akt/eNOS, Nrf2/HO-1, MAPK signaling pathways, and Insulin signal transduction pathways were positively modulated by morin pre-treatment.

Conclusions: Morin attenuated oxidative stress and inflammation and also modified the activity of various molecular pathways to mitigate cardiomyocyte damage during ISO-induced MI in diabetic rats.

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莫林通过调节炎症途径改善糖尿病大鼠的心肌损伤

背景：糖尿病患者的高血糖水平会导致血管炎症，从而加速动脉粥样硬化。在此，以 40 毫克/千克的剂量连续 28 天给雄性 Wistar 大鼠口服 Morin，并在第 27 天和第 28 天以 85 毫克/千克的剂量给指定组静脉注射 ISO，以诱发心肌梗死：结果：服用 ISO 后，糖尿病患者体内产生的自由基（包括 ROS）会激活细胞凋亡的内在和外在途径。Morin 能明显（p ≤ 0.05）降低氧化应激（GSH、MDA、SOD）、心脏损伤指标（CK-MB、LDH）、炎症（TNF、IL-6）和细胞凋亡（Bax、BCl2、Caspase-3）。此外，它还能降低胰岛素和血糖水平。Akt/eNOS、Nrf2/HO-1、MAPK 信号通路和胰岛素信号转导通路受到吗啉预处理的积极调节：结论：在 ISO 诱导的糖尿病大鼠心肌梗死过程中，吗啉可减轻氧化应激和炎症反应，并改变各种分子通路的活性，从而减轻心肌细胞损伤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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