Clinical bleeding diathesis, laboratory haemostatic aberrations and survival in dogs infected with Angiostrongylus vasorum: 180 cases (2005-2019)

IF 1.7 2区农林科学 Q2 VETERINARY SCIENCES

Journal of Small Animal Practice Pub Date : 2024-02-08 DOI:10.1111/jsap.13701

A. S. Thomsen, M. P. Petersen, J. L. Willesen, M. B. T. Bach, I. N. Kieler, A. T. Kristensen, J. Koch, L. N. Nielsen

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Abstract

Objectives

Bleeding diathesis is a complication in dogs infected with Angiostrongylus vasorum. This retrospective study investigated clinical and laboratory haemostatic differences in A. vasorum-positive dogs with and without signs of bleeding and impact of bleeding on survival.

Materials and Methods

Demographics, type of clinical bleeding, haematocrit and a range of haemostatic tests, including thromboelastography and derived velocity curves were retrospectively registered from A. vasorum-positive dogs. All parameters were compared between dogs with and without signs of bleeding using univariable analyses. Binomial and multinomial regression models were applied to examine specific indicators in the bleeding dogs. P-values were false discovery rate adjusted, and adjusted P<0.05 was considered significant.

Results

One hundred and eighty dogs entered the study, including 65 dogs (36.1%) presenting with bleeding diathesis. Different types of cutaneous and mucosal bleeding were the most common clinical findings. Twenty dogs presented with neurological signs associated with intracranial and intra-spinal bleeding. One hundred and thirty-seven dogs had haematological and/or haemostatic laboratory analyses performed. Haematocrit, platelet count, thromboelastographic angle, maximum amplitude, global clot strength, maximum rate of thrombin generation and total thrombin generation were decreased, while prothrombin time was prolonged in bleeding dogs. Survival rate of bleeding dogs was lower at hospital discharge (76.9%) and 1 month after diagnosis (66.0%) than in dogs without signs of bleeding (94.8% and 90.1% at discharge and at 1 month, respectively).

Clinical Significance

Several haemostatic aberrations were detected in A. vasorum-positive dogs with bleeding diathesis. Bleeding was identified as an important negative prognostic indicator in A. vasorum-positive dogs.

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感染 Angiostrongylus vasorum 的狗的临床出血症状、实验室止血畸变和存活率：180 个病例（2005-2019 年）

目的：出血是狗感染血管瘤弧菌后的一种并发症。这项回顾性研究调查了有出血迹象和无出血迹象的血管甲虫阳性犬在临床和实验室止血方面的差异，以及出血对存活率的影响：对血管瘤病毒阳性犬的人口统计学特征、临床出血类型、血细胞比容和一系列止血测试（包括血栓弹性成像和衍生速度曲线）进行了回顾性登记。使用单变量分析比较了有出血迹象和无出血迹象的狗的所有参数。二项式和多项式回归模型用于检查出血犬的特定指标。P值为经调整的误发现率和调整后的PR结果：180 只狗参加了研究，其中 65 只（36.1%）出现出血症状。不同类型的皮肤和粘膜出血是最常见的临床表现。20 只狗出现了与颅内和脊髓内出血相关的神经症状。137 只狗进行了血液学和/或止血实验室分析。出血犬的血细胞比容、血小板计数、血栓弹力图角度、最大振幅、整体凝块强度、凝血酶生成最大速率和凝血酶生成总量均下降，凝血酶原时间延长。出血犬出院时的存活率（76.9%）和确诊后 1 个月的存活率（66.0%）低于无出血症状的犬（出院时的存活率为 94.8%，确诊后 1 个月的存活率为 90.1%）：临床意义：在A. vasorum阳性的出血病犬中发现了几种止血异常。在血管瘤病毒阳性犬中，出血被认为是一个重要的不良预后指标。

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来源期刊

Journal of Small Animal Practice 农林科学-兽医学

CiteScore

3.30

自引率

6.20%

发文量

117

审稿时长

12-24 weeks

期刊介绍： Journal of Small Animal Practice (JSAP) is a monthly peer-reviewed publication integrating clinical research papers and case reports from international sources, covering all aspects of medicine and surgery relating to dogs, cats and other small animals. These papers facilitate the dissemination and implementation of new ideas and techniques relating to clinical veterinary practice, with the ultimate aim of promoting best practice. JSAP publishes high quality original articles, as well as other scientific and educational information. New developments are placed in perspective, encompassing new concepts and peer commentary. The target audience is veterinarians primarily engaged in the practise of small animal medicine and surgery. In addition to original articles, JSAP will publish invited editorials (relating to a manuscript in the same issue or a topic of current interest), review articles, which provide in-depth discussion of important clinical issues, and other scientific and educational information from around the world. The final decision on publication of a manuscript rests with the Editorial Board and ultimately with the Editor. All papers, regardless of type, represent the opinion of the authors and not necessarily that of the Editor, the Association or the Publisher. The Journal of Small Animal Practice is published on behalf of the British Small Animal Veterinary Association and is also the official scientific journal of the World Small Animal Veterinary Association