Enhancing Oral Mucosal Barrier, Mitigating Microinflammation, and Addressing Malnutrition in Dialysis Patients: The Impact of Tangerine Peel Lemon Glycerin.

IF 1.9 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Alternative therapies in health and medicine Pub Date : 2024-10-01

Hua Ao, Yong-Qiang Liu, Sen-Lin Qian, Jun Dou, Xiao Zheng, Qiu-Shuang Xu, Ming Li

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引用次数: 0

Abstract

Objective: This study investigates the efficacy of tangerine peel lemon glycerin extract oral spray in improving oral mucosal barrier, reducing microinflammation, and addressing malnutrition in maintenance dialysis (MHD) patients.

Methods: Tangerine peel and dry lemon underwent glycerin extraction. From January 2021 to June 2022, 72 MHD patients with thirst were prospectively chosen at Sinopharm Gezhouba Central Hospital. Randomization divided them into an observation group (n=36) and a control group (n=36). Both received routine maintenance dialysis and chronic kidney disease management. Oral conditions were assessed using OHIP-14, a homemade visual thirst score scale, SFR, sAA, and saliva pH. Microinflammatory indexes (CRP, TNF-α, IL-6) and nutritional status indicators (Alb, PA, Hb) were measured. The observation group used 1ml of tangerine peel lemon glycerin extract with a pH value of 5.9~6.1 q6h, while the control group used 1ml of purified water q6h.

Results: After 3 months, the observation group showed significant improvement in OHIP-14 and visual thirst score scale (P < .01). Saliva pH, CRP, TNF-α, and IL-6 levels decreased, and SAA activity, SFR, Alb, PA, and Hb levels increased significantly in the observation group compared to the control group (P < .01).

Conclusions: Tangerine peel lemon glycerin spray demonstrates promise in improving the oral mucosal barrier, exhibiting antibacterial and anti-inflammatory properties that mitigate microinflammation and malnutrition. This finding suggests a connection between oral health, systemic pathology, psychological state, and social adaptability.

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增强透析患者的口腔黏膜屏障、减轻微炎症和解决营养不良问题：橘皮柠檬甘油的影响。

研究目的本研究探讨了橘皮柠檬甘油提取物口腔喷雾剂在改善维持性透析（MHD）患者口腔黏膜屏障、减少微炎症和解决营养不良问题方面的功效：方法：对橘皮和干柠檬进行甘油提取。2021年1月至2022年6月，在国药集团葛洲坝中心医院前瞻性地选择了72名患有消渴症的维持性透析（MHD）患者。随机分为观察组（36 人）和对照组（36 人）。两组均接受常规维持性透析和慢性肾脏病管理。使用自制的视觉口渴评分量表 OHIP-14、SFR、sAA 和唾液 pH 对口腔状况进行评估。测量微炎症指标（CRP、TNF-α、IL-6）和营养状况指标（Alb、PA、Hb）。观察组每 6 小时使用 1 毫升 pH 值为 5.9~6.1 的橘皮柠檬甘油提取物，对照组每 6 小时使用 1 毫升纯净水：3个月后，观察组的OHIP-14和口渴视觉评分量表均有显著改善（P < .01）。与对照组相比，观察组的唾液 pH 值、CRP、TNF-α 和 IL-6 水平降低，SAA 活性、SFR、Alb、PA 和 Hb 水平显著升高（P < .01）：橘皮柠檬甘油喷雾剂有望改善口腔黏膜屏障，其抗菌和消炎特性可减轻微炎症和营养不良。这一发现表明，口腔健康、系统病理、心理状态和社会适应能力之间存在联系。

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来源期刊

Alternative therapies in health and medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

0.90

自引率

0.00%

发文量

219

期刊介绍： Launched in 1995, Alternative Therapies in Health and Medicine has a mission to promote the art and science of integrative medicine and a responsibility to improve public health. We strive to maintain the highest standards of ethical medical journalism independent of special interests that is timely, accurate, and a pleasure to read. We publish original, peer-reviewed scientific articles that provide health care providers with continuing education to promote health, prevent illness, and treat disease. Alternative Therapies in Health and Medicine was the first journal in this field to be indexed in the National Library of Medicine. In 2006, 2007, and 2008, ATHM had the highest impact factor ranking of any independently published peer-reviewed CAM journal in the United States—meaning that its research articles were cited more frequently than any other journal’s in the field. Alternative Therapies in Health and Medicine does not endorse any particular system or method but promotes the evaluation and appropriate use of all effective therapeutic approaches. Each issue contains a variety of disciplined inquiry methods, from case reports to original scientific research to systematic reviews. The editors encourage the integration of evidence-based emerging therapies with conventional medical practices by licensed health care providers in a way that promotes a comprehensive approach to health care that is focused on wellness, prevention, and healing. Alternative Therapies in Health and Medicine hopes to inform all licensed health care practitioners about developments in fields other than their own and to foster an ongoing debate about the scientific, clinical, historical, legal, political, and cultural issues that affect all of health care.