Efficacy of Black Gold, Delicate Pulse Light, Super Photon Skin Rejuvenation for Pigmented Dermatoses.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-10-01

Mi Zhou, Na Xu, Shaobo Lan, Wenfang Liu

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引用次数: 0

Abstract

Context: Pigmented dermatoses are skin diseases characterized by pigmentation changes in the skin's surface due to abnormal melanocyte production. Photon-skin-rejuvenation technology can be effective for the management of facial pigmented dermatoses. Black Gold Delicate Pulse Light (DPL) Super Photon Skin Rejuvenation therapy is a new technology based on traditional photo rejuvenation.

Objective: The study intended to evaluate the therapeutic efficacy of DPL therapy in the management of targeted pigmented skin diseases, such as melasma, solar lentigines, and postinflammatory hyperpigmentation.

Design: The research team conducted a prospective cohort study.

Setting: The study took place at Department of Dermatology, Affiliated Hospital of Shaoxing University, Shaoxing, China.

Participants: Participants were 130 patients with facial pigmented dermatoses treated at the hospital between February 2021 and December 2021.

Interventions: The research team assigned participants to one of two groups, with 65 participants in each group: (1) the control group, the intense pulsed light (IPL) group, who received IPL treatment, and (2) the intervention group, the DPL group, who received black gold DPL super photon skin rejuvenation. Both groups received the treatments once a month for 6 months.

Outcome measures: At baseline and postintervention for both groups, the research team: (1) collected 5 ml of fasting venous blood from participants and measured serum concentrations of melatonin (MEL), vascular endothelial growth factor (VEGF) and endothelin-1 (ET-1) using enzyme-linked immunosorbent assay (ELISA); (2) assessed the degree of reduction of facial pigmentation using the Visia skin test and each participant's clinical results and calculated total efficacy; and (3) monitored and recorded adverse events.

Results: Compared to the IPL group, the DPL group: (1) had greater symptom mitigation of the facial pigmented dermatosis, as evinced by significantly lower serum MEL (P = .001) and ET-1 (P = .020) concentrations and higher VEGF levels (P = .001); (2) for participants with freckles (P = .045), cafe-au-lait spots (P = .021), or post-acne hyperpigmentation (P = .029), had a significantly higher total efficacy; and (3) had a lower incidence of adverse events (P = .041).

Conclusions: Black Gold DPL Super Photon Skin Rejuvenation offers a significantly higher safety profile and treatment efficacy for pigmented-skin diseases compared to IPL treatment. These promising results suggest potential for its use in clinical practice, but clinical adoption requires future trials.

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黑金、精细脉冲光、超级光子嫩肤对色素性皮肤病的疗效。

背景：色素性皮肤病是一种皮肤疾病，其特征是皮肤表面因黑色素细胞生成异常而出现色素变化。光子嫩肤技术可有效治疗面部色素性皮肤病。黑金精密脉冲光（DPL）超级光子嫩肤疗法是一种基于传统光子嫩肤的新技术：研究旨在评估 DPL 疗法在治疗黄褐斑、日光性色斑和炎症后色素沉着等目标色素性皮肤病方面的疗效：研究小组进行了一项前瞻性队列研究：研究地点：中国绍兴，绍兴大学附属医院皮肤科：干预措施：研究小组将参与者分为两组，每组65人：（1）对照组，即强脉冲光（IPL）组，接受IPL治疗；（2）干预组，即DPL组，接受黑金DPL超级光子嫩肤治疗。两组均每月接受一次治疗，为期 6 个月：在两组的基线和干预后，研究小组：(1) 采集参与者的 5 毫升空腹静脉血，使用酶联免疫吸附试验（ELISA）测量血清中褪黑素（MEL）、血管内皮生长因子（VEGF）和内皮素-1（ET-1）的浓度；(2) 使用 Visia 皮肤测试和每位参与者的临床结果评估面部色素沉着的减少程度，并计算总疗效；(3) 监测和记录不良事件：结果：与 IPL 组相比，DPL 组：(1) 面部色素性皮肤病的症状减轻程度更大，表现为血清 MEL（P = .001）和 ET-1 （P = .020）浓度显著降低，血管内皮生长因子（VEGF）水平升高（P = .001）；（2）对于有雀斑（P = .045）、咖啡斑（P = .021）或痤疮后色素沉着（P = .029）的参与者，总疗效明显更高；以及（3）不良事件发生率较低（P = .041）：结论：与 IPL 治疗相比，黑金 DPL 超级光子嫩肤治疗色素性皮肤疾病的安全性和疗效明显更高。这些令人鼓舞的结果表明，黑金 DPL 超级光子嫩肤有可能应用于临床实践，但临床应用还需要未来的试验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.