Associations between Sleep Disorders and Impulsive-Compulsive Behaviors in Parkinson's Disease: A Prospective Cohort Study.

IF 3.2 3区 医学 Q2 CLINICAL NEUROLOGY
Neuroepidemiology Pub Date : 2024-01-01 Epub Date: 2024-02-07 DOI:10.1159/000536555
Meijie Ye, Xiaoying Kang, Ida K Karlsson, Yu Wang, Qianqian Ji, Qi Liu, Xiaowei Xu, Sara Hägg, Fang Fang, Karin Wirdefeldt, Yiqiang Zhan
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Abstract

Objective: To examine the associations of excessive daytime sleepiness (EDS) and probable rapid eye movement sleep behavior disorder (pRBD), respectively, with impulsive-compulsive behaviors (ICBs) over a 5-year follow-up in patients with early Parkinson's disease (PD).

Methods: The Parkinson's Progression Markers Initiative is a multicenter cohort study based on an ongoing and open-ended registry. Longitudinal associations of sleep disorders with ICB over 5-year follow-up visits were estimated using generalized linear mixed-effects models among PD participants.

Results: A total of 825 PD participants were enrolled at baseline. The study sample had a median baseline age of 63.1 (interquartile range: 55.6-69.3) years and comprised 496 (61.5%) men. Among them, 201 (24.9%) had ICB at baseline. In the generalized mixed-effects models, EDS (odds ratio [OR] = 1.09, 95% confidence interval [CI] 1.05, 1.12) and RBD (OR = 1.07, 95% CI 1.03, 1.12) were substantially associated with higher odds of developing ICB over time in PD patients, after multivariate adjustment including age, gender, family history, GDS score, STAI-Y score, MDS-UPDRS part III score, LEDD, and disease duration. Consistent results were observed when stratifying by age at baseline, gender, and PD family history.

Conclusions: The study findings suggest a longitudinal association between EDS and pRBD with an increased risk of developing ICB in patients with PD. The findings emphasize the significance of evaluating and addressing sleep disorders in PD patients as a potential approach to managing ICB.

帕金森病患者睡眠障碍与冲动-强迫行为之间的关系:前瞻性队列研究
目的研究早期帕金森病(PD)患者在5年随访期间白天过度嗜睡(EDS)和可能的眼球快速运动睡眠行为障碍(pRBD)分别与冲动-强迫行为(ICB)之间的关系:帕金森病进展标志物倡议是一项多中心队列研究,基于一个正在进行的开放式登记册。采用广义线性混合效应模型估计了帕金森病参与者在5年随访期间睡眠障碍与ICB的纵向关系:共有 825 名帕金森病患者进行了基线登记。研究样本的基线年龄中位数为 63.1 岁(四分位数间距 [IQR]:55.6-69.3),其中男性 496 人(61.5%)。其中,201 人(24.9%)在基线时患有 ICB。在广义混合效应模型中,经年龄、性别、家族史、GDS评分、STAI-Y评分、MDS-UPDRS第三部分评分、LEDD和病程等多变量调整后,EDS(几率比[OR]=1.09,95%置信区间[CI]1.05, 1.12)和RBD(OR=1.07,95%置信区间[CI]1.03, 1.12)与PD患者随着时间推移患ICB的几率较高密切相关。根据基线年龄、性别和帕金森病家族史进行分层后,结果一致:研究结果表明,EDS 和 pRBD 与帕金森病患者罹患 ICB 的风险增加之间存在纵向联系。研究结果强调了评估和解决帕金森病患者睡眠障碍的重要性,这是控制 ICB 的一种潜在方法。
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来源期刊
Neuroepidemiology
Neuroepidemiology 医学-公共卫生、环境卫生与职业卫生
CiteScore
9.90
自引率
1.80%
发文量
49
审稿时长
6-12 weeks
期刊介绍: ''Neuroepidemiology'' is the only internationally recognised peer-reviewed periodical devoted to descriptive, analytical and experimental studies in the epidemiology of neurologic disease. The scope of the journal expands the boundaries of traditional clinical neurology by providing new insights regarding the etiology, determinants, distribution, management and prevention of diseases of the nervous system.
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