Ho(III)-coordination Complex: Fluorescence Performances and Combined with Captopril-Hydrogels against Glioma.

IF 2.6 4区化学 Q2 BIOCHEMICAL RESEARCH METHODS

Journal of Fluorescence Pub Date : 2025-03-01 Epub Date: 2024-02-08 DOI:10.1007/s10895-024-03600-4

Yuwei Cong, Tingting Zhang, Heng Li, Jie Pan, Jiping Qiu

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引用次数: 0

Abstract

In this study, a novel dinuclear lanthanide complex, denoted as [Ho₂(L)₂(acac)₂(CH₃OH)₂]·CH₃OH (1) (where H₂L is 2-[((4-methyl)-2-(carboxyl)-imino)]methyl]-8-hydroxyquinoline, and Hacac is acetylacetonate), was successfully synthesized and characterized using single-crystal and elemental analysis, with the auxiliary ligand β-diketonate and the 8-hydroxyquinoline Schiff base derivative serving as the foundation. Through ligand-to-metal charge transfer, Compound 1 demonstrated remarkable green fluorescence properties, showcasing potential applications in green fluorescence materials and fluorescence sensing. Additionally, Hyaluronic Acid (HA)/Carboxymethyl Chitosan (CMCS) hydrogels were synthesized through a chemical method. Utilizing captopril as a drug model, a novel metal gel granule of captopril was developed and assessed for its inhibitory activity against glioma cells. Molecular docking simulations revealed that only the methanol group in the Ho complex could contribute a polar atom for the formation of binding interactions.

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Ho(III)配位复合物：荧光性能及结合卡托普利水凝胶抗胶质瘤。

本研究成功合成了一种新型双核镧系配合物，命名为 [Ho2(L)2(acac)2(CH3OH)2]-CH3OH（1）（其中 H2L 为 2-[[((4-甲基)-2-(羧基)-亚氨基)]甲基]-8-羟基喹啉，Hacac 为乙酰丙酮）、以辅助配体 β-二酮酸酯和 8-羟基喹啉希夫碱衍生物为基础，成功合成了该化合物，并利用单晶和元素分析对其进行了表征。通过配体到金属的电荷转移，化合物 1 显示出显著的绿色荧光特性，展示了其在绿色荧光材料和荧光传感方面的潜在应用。此外，还通过化学方法合成了透明质酸（HA）/羧甲基壳聚糖（CMCS）水凝胶。以卡托普利为药物模型，开发了一种新型卡托普利金属凝胶颗粒，并评估了其对胶质瘤细胞的抑制活性。分子对接模拟显示，Ho 复合物中只有甲醇基团能提供极性原子以形成结合相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Fluorescence 化学-分析化学

CiteScore

4.60

自引率

7.40%

发文量

203

审稿时长

5.4 months

期刊介绍： Journal of Fluorescence is an international forum for the publication of peer-reviewed original articles that advance the practice of this established spectroscopic technique. Topics covered include advances in theory/and or data analysis, studies of the photophysics of aromatic molecules, solvent, and environmental effects, development of stationary or time-resolved measurements, advances in fluorescence microscopy, imaging, photobleaching/recovery measurements, and/or phosphorescence for studies of cell biology, chemical biology and the advanced uses of fluorescence in flow cytometry/analysis, immunology, high throughput screening/drug discovery, DNA sequencing/arrays, genomics and proteomics. Typical applications might include studies of macromolecular dynamics and conformation, intracellular chemistry, and gene expression. The journal also publishes papers that describe the synthesis and characterization of new fluorophores, particularly those displaying unique sensitivities and/or optical properties. In addition to original articles, the Journal also publishes reviews, rapid communications, short communications, letters to the editor, topical news articles, and technical and design notes.