Well-differentiated Squamous Cell Carcinoma With Sarcomatous Differentiation in Patient With a History of Recurrent Verrucous Carcinoma.

IF 1.6 4区 医学 Q3 OBSTETRICS & GYNECOLOGY
Komal Ijaz, Eric Johannesen, Van Nguyen T
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引用次数: 0

Abstract

Human papillomavirus-independent vulvar squamous cell carcinoma has a peak incidence in about the eighth decade of life. A variable portion of the vulvar squamous cell carcinoma are human papillomavirus-independent comprising 20% to 80% of all cases. Verrucous carcinoma (VC) is part of the spectrum of human papillomavirus-independent carcinomas and its combination with well-differentiated squamous cell carcinoma with sarcomatous differentiation is an extremely unusual neoplasm. The available literature on VC is currently limited to case reports and small single-institution studies. Here, we present a case concerning an 81-year-old woman with a history of chronic itching, swelling, and lichen sclerosis with variable-sized multiple white-pink plaques of the vulva. The pathologic diagnosis of VC was made. The patient later on developed multiple lesions of biopsy proved VC and most recent biopsy shows well-differentiated squamous cell carcinoma with abrupt sarcomatous differentiation. A review of the literature shows the rarity of this lesion of the female genital tract. Clinicians and patients should be aware of the aggressive behavior of cancers and adjust their surgical management together with the follow-up strategy. To the best of our knowledge, this is the first description of a VC and well-differentiated squamous cell carcinoma with abrupt sarcomatous differentiation occurring in the vulva.

有复发性疣状癌病史的患者体内分化良好的鳞状细胞癌伴有肉瘤。
人类乳头瘤病毒独立型外阴鳞状细胞癌的发病高峰期大约在人的第八个十年。外阴鳞状细胞癌中有一部分与人类乳头状瘤病毒无关,占所有病例的20%至80%。疣状癌(VC)是人类乳头瘤病毒不依赖性癌谱的一部分,它与肉瘤样分化的分化良好的鳞状细胞癌相结合,是一种极为罕见的肿瘤。目前,关于VC的文献仅限于病例报告和单个机构的小型研究。在此,我们介绍一例病例,患者是一名 81 岁的妇女,有慢性瘙痒、肿胀和苔藓样硬化病史,外阴有大小不等的多发性白色粉红色斑块。病理诊断为外阴癌。后来,患者又出现了活组织检查证实的多发性外阴阴道炎病变,最近的活组织检查结果显示为分化良好的鳞状细胞癌,并伴有肉瘤样分化。文献综述显示,这种女性生殖道病变非常罕见。临床医生和患者应认识到癌症的侵袭性,并调整手术治疗和随访策略。据我们所知,这是首次描述发生在外阴的VC和分化良好的鳞状细胞癌伴有突发性肉瘤分化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.90
自引率
12.50%
发文量
154
审稿时长
6-12 weeks
期刊介绍: International Journal of Gynecological Pathology is the official journal of the International Society of Gynecological Pathologists (ISGyP), and provides complete and timely coverage of advances in the understanding and management of gynecological disease. Emphasis is placed on investigations in the field of anatomic pathology. Articles devoted to experimental or animal pathology clearly relevant to an understanding of human disease are published, as are pathological and clinicopathological studies and individual case reports that offer new insights.
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