Exploring Dendritic and Spine Structural Profiles in Epilepsy: Insights From Human Studies and Experimental Animal Models.

IF 5.8 2区 医学 Q1 CLINICAL NEUROLOGY
Epilepsy Currents Pub Date : 2023-12-27 eCollection Date: 2024-01-01 DOI:10.1177/15357597231218603
Shikha Kumari, Amy L Brewster
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引用次数: 0

Abstract

Dendrites are tree-like structures with tiny spines specialized to receive excitatory synaptic transmission. Spino-dendritic plasticity, driven by neural activity, underlies the maintenance of neuronal connections crucial for proper circuit function. Abnormalities in dendritic morphology are frequently seen in epilepsy. However, the exact etiology or functional implications are not yet known. Therefore, to better comprehend the structure-function significance of this dendritic pathology in epilepsy, it is necessary to identify the common spino-dendritic disturbances present in both human and experimental models. Here, we describe the dendritic and spine structural profiles found across human refractory epilepsy as well as in animal models of developmental, acquired, and genetic epilepsies.

探索癫痫的树突和脊柱结构特征:人类研究和实验动物模型的启示。
树突是一种树状结构,具有专门接收兴奋性突触传递的微小棘突。神经活动驱动的棘突-树突可塑性是维持神经元连接的基础,而神经元连接对电路功能的正常发挥至关重要。树突形态异常经常见于癫痫。然而,确切的病因或功能影响尚不清楚。因此,为了更好地理解这种树突病理学在癫痫中的结构-功能意义,有必要确定人类和实验模型中常见的棘树突紊乱。在这里,我们描述了在人类难治性癫痫以及发育性、获得性和遗传性癫痫动物模型中发现的树突和棘突结构特征。
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来源期刊
Epilepsy Currents
Epilepsy Currents CLINICAL NEUROLOGY-
CiteScore
2.40
自引率
5.60%
发文量
88
审稿时长
>12 weeks
期刊介绍: Epilepsy Currents is an open access, bi-monthly current-awareness journal providing reviews, commentaries and abstracts from the world’s literature on the research and treatment of epilepsy. Epilepsy Currents surveys and comments on all important research and developments in a format that is easy to read and reference. Each issue is divided into two main sections: Basic Science and Clinical Science. An outstanding Editorial Board reviews the literature and assigns topics and articles to world experts for comment. In addition, the Editors commission authoritative review articles on important subjects.
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