Emerging roles of deubiquitinating enzymes in actin cytoskeleton and tumor metastasis.

IF 6.6 2区医学 Q1 Medicine

Cellular Oncology Pub Date : 2024-08-01 Epub Date: 2024-02-07 DOI:10.1007/s13402-024-00923-z

Ying Xue, Cong Xue, Wei Song

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引用次数: 0

Abstract

Background: Metastasis accounts for the majority of cancer-related deaths. Actin dynamics and actin-based cell migration and invasion are important factors in cancer metastasis. Metastasis is characterized by actin polymerization and depolymerization, which are precisely regulated by molecular changes involving a plethora of actin regulators, including actin-binding proteins (ABPs) and signalling pathways, that enable cancer cell dissemination from the primary tumour. Research on deubiquitinating enzymes (DUBs) has revealed their vital roles in actin dynamics and actin-based migration and invasion during cancer metastasis.

Conclusion: Here, we review how DUBs drive tumour metastasis by participating in actin rearrangement and actin-based migration and invasion. We summarize the well-characterized and essential actin cytoskeleton signalling molecules related to DUBs, including Rho GTPases, Src kinases, and ABPs such as cofilin and cortactin. Other DUBs that modulate actin-based migration signalling pathways are also discussed. Finally, we discuss and address therapeutic opportunities and ongoing challenges related to DUBs with respect to actin dynamics.

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去泛素化酶在肌动蛋白细胞骨架和肿瘤转移中的新作用

背景：转移占癌症相关死亡的大多数。肌动蛋白动力学和基于肌动蛋白的细胞迁移和侵袭是癌症转移的重要因素。转移的特点是肌动蛋白的聚合和解聚，这是由涉及大量肌动蛋白调控因子（包括肌动蛋白结合蛋白（ABPs）和信号通路）的分子变化精确调控的，从而使癌细胞从原发肿瘤扩散。对去泛素化酶（DUBs）的研究揭示了它们在癌症转移过程中肌动蛋白动力学以及基于肌动蛋白的迁移和侵袭中的重要作用：在此，我们回顾了 DUBs 如何通过参与肌动蛋白重排以及基于肌动蛋白的迁移和侵袭来驱动肿瘤转移。我们总结了与 DUBs 有关的特征明确且重要的肌动蛋白细胞骨架信号分子，包括 Rho GTPases、Src 激酶和 ABPs（如 cofilin 和 cortactin）。我们还讨论了调节基于肌动蛋白的迁移信号通路的其他 DUBs。最后，我们讨论并探讨了与肌动蛋白动力学相关的 DUBs 的治疗机会和当前挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cellular Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

10.40

自引率

1.50%

发文量

审稿时长

16 weeks

期刊介绍： The Official Journal of the International Society for Cellular Oncology Focuses on translational research Addresses the conversion of cell biology to clinical applications Cellular Oncology publishes scientific contributions from various biomedical and clinical disciplines involved in basic and translational cancer research on the cell and tissue level, technical and bioinformatics developments in this area, and clinical applications. This includes a variety of fields like genome technology, micro-arrays and other high-throughput techniques, genomic instability, SNP, DNA methylation, signaling pathways, DNA organization, (sub)microscopic imaging, proteomics, bioinformatics, functional effects of genomics, drug design and development, molecular diagnostics and targeted cancer therapies, genotype-phenotype interactions. A major goal is to translate the latest developments in these fields from the research laboratory into routine patient management. To this end Cellular Oncology forms a platform of scientific information exchange between molecular biologists and geneticists, technical developers, pathologists, (medical) oncologists and other clinicians involved in the management of cancer patients. In vitro studies are preferentially supported by validations in tumor tissue with clinicopathological associations.