TB-free Ebeye: Results from integrated TB and noncommunicable disease case finding in Ebeye, Marshall Islands

IF 1.9 Q3 INFECTIOUS DISEASES

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases Pub Date : 2024-02-03 DOI:10.1016/j.jctube.2024.100418

Richard J. Brostrom , Angela Largen , Joaquin N. Nasa , Glorine Jeadrik , Seiji Yamada , Subhash Yadav , Eunyoung Ko , Jon V. Warkentin , Terence L. Chorba

{"title":"TB-free Ebeye: Results from integrated TB and noncommunicable disease case finding in Ebeye, Marshall Islands","authors":"Richard J. Brostrom , Angela Largen , Joaquin N. Nasa , Glorine Jeadrik , Seiji Yamada , Subhash Yadav , Eunyoung Ko , Jon V. Warkentin , Terence L. Chorba","doi":"10.1016/j.jctube.2024.100418","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Tuberculosis (TB) incidence rates in the Republic of the Marshall Islands are among the highest in the world, 480/100,000 in 2017. In response, the Health Ministry completed islandwide screening in Ebeye Island in 2017.</p></div><div><h3>Methods</h3><p>Participants were interviewed to obtain TB history, exposures, and symptoms. TB assessment included chest radiography with sputum collection for GeneXpert® MTB-RIF if indicated. TB diagnosis was made by consensus of visiting TB experts. Participants were also screened for Hansen’s disease (HD) and diabetes mellitus (DM). For persons aged ≥21 years, blood pressure, cholesterol, and blood glucose were assessed.</p></div><div><h3>Results</h3><p>A total of 5,166 persons (90.0 % of target population) completed screening leading to the identification of 39 new cases of TB (755/100,000) and 14 persons with HD (270/100,000). DM was detected in 1,096 persons (27 %), including in 351 persons not previously diagnosed. The rate of hypertension was 61 % and of hypercholesterolemia was 15 %. New or prevalent TB diagnosis was associated with newly diagnosed or history of DM (aOR 4.68, 2.15–10.20).</p></div><div><h3>Conclusions</h3><p>In Ebeye, an integrated TB screening campaign found TB, HD, DM, and hypertension. TB and DM were strongly associated.</p></div>","PeriodicalId":37942,"journal":{"name":"Journal of Clinical Tuberculosis and Other Mycobacterial Diseases","volume":"35 ","pages":"Article 100418"},"PeriodicalIF":1.9000,"publicationDate":"2024-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2405579424000056/pdfft?md5=17b59b45e142a2a0272dc3ec8235b4bf&pid=1-s2.0-S2405579424000056-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Tuberculosis and Other Mycobacterial Diseases","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405579424000056","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Tuberculosis (TB) incidence rates in the Republic of the Marshall Islands are among the highest in the world, 480/100,000 in 2017. In response, the Health Ministry completed islandwide screening in Ebeye Island in 2017.

Methods

Participants were interviewed to obtain TB history, exposures, and symptoms. TB assessment included chest radiography with sputum collection for GeneXpert® MTB-RIF if indicated. TB diagnosis was made by consensus of visiting TB experts. Participants were also screened for Hansen’s disease (HD) and diabetes mellitus (DM). For persons aged ≥21 years, blood pressure, cholesterol, and blood glucose were assessed.

Results

A total of 5,166 persons (90.0 % of target population) completed screening leading to the identification of 39 new cases of TB (755/100,000) and 14 persons with HD (270/100,000). DM was detected in 1,096 persons (27 %), including in 351 persons not previously diagnosed. The rate of hypertension was 61 % and of hypercholesterolemia was 15 %. New or prevalent TB diagnosis was associated with newly diagnosed or history of DM (aOR 4.68, 2.15–10.20).

Conclusions

In Ebeye, an integrated TB screening campaign found TB, HD, DM, and hypertension. TB and DM were strongly associated.

查看原文本刊更多论文

无结核病的埃贝耶：马绍尔群岛埃贝耶综合结核病和非传染性疾病病例调查的结果

背景马绍尔群岛共和国的结核病（TB）发病率位居世界前列，2017年为480/100,000。为此，卫生部于 2017 年在埃贝耶岛完成了全岛筛查。方法对参与者进行访谈，以了解结核病史、暴露情况和症状。结核病评估包括胸片检查，如有必要，还需收集痰液进行 GeneXpert® MTB-RIF。肺结核诊断由到访的肺结核专家一致做出。参与者还接受了汉森氏病（HD）和糖尿病（DM）筛查。共有 5,166 人（占目标人群的 90.0%）完成了筛查，结果发现 39 例新肺结核病例（755/100,000）和 14 例汉森氏病患者（270/100,000）。有 1,096 人（27%）被查出患有糖尿病，其中包括 351 名之前未确诊的患者。高血压发病率为 61%，高胆固醇血症发病率为 15%。结论在埃贝耶，结核病综合筛查活动发现了结核病、高密度脂蛋白血症、糖尿病和高血压。肺结核与糖尿病密切相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases Medicine-Pulmonary and Respiratory Medicine

CiteScore

4.00

自引率

5.00%

发文量

审稿时长

30 weeks

期刊介绍： Journal of Clinical Tuberculosis and Mycobacterial Diseases aims to provide a forum for clinically relevant articles on all aspects of tuberculosis and other mycobacterial infections, including (but not limited to) epidemiology, clinical investigation, transmission, diagnosis, treatment, drug-resistance and public policy, and encourages the submission of clinical studies, thematic reviews and case reports. Journal of Clinical Tuberculosis and Mycobacterial Diseases is an Open Access publication.