Functional Abnormality of the Reward System in Depressed Adolescents and Young Adults with and without Suicidal Behavior.

IF 2.3 3区医学 Q3 CLINICAL NEUROLOGY

Brain Topography Pub Date : 2024-09-01 Epub Date: 2024-02-06 DOI:10.1007/s10548-024-01036-4

Haitang Qiu, Jun Cao, Rui Wang, Xinke Li, Li Kuang, Zhubin Ouyang

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Abstract

Objective: To identify local and functional connectivity abnormalities in the brain's reward network in depressed adolescents and young adults with and without suicidal behavior.

Methods: Magnetic resonance imaging data were obtained from 41 major depressive disorder (MDD) patients with suicidal behavior (sMDD, males/females: 12/29), 44 MDD patients without suicidal behavior (nMDD, males/females: 13/32), and 52 healthy controls (HCs, males/females: 17/35). The Young Mania Scale, Hamilton Depression Scale, Columbia Suicide Scale, and Scale for Suicide Ideation were used to evaluate emotional state and suicidal ideation and behaviors. The amplitude of low frequency fluctuations (ALFF), regional homogeneity (ReHo) and functional connectivity of 11 regions of interest (ROIs) in the reward network were determined.

Results: ALFF values in the vmPFC of the nMDD group were significantly lower than those in the HC group (p = 0.031). The ReHo values of the nMDD group were lower in the lVS but higher in the vmPFC than those of the HC group (P = 0.018 and 0.025, respectively). Functional connectivity of the AC with the vmPFC, lVS, rVS, and vmPFC was increased in the sMDD group compared with that in the nMDD group (P = 0.038, 0.034, 0.006, respectively).

Conclusion: Local and functional connectivity abnormalities in the reward network were found in the MDD groups. However, increased functional connectivity was found in only the sMDD group.

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有自杀行为和无自杀行为的抑郁青少年和青年奖励系统功能异常。

目的确定有自杀行为和无自杀行为的青少年抑郁症患者大脑奖赏网络的局部和功能连接异常：磁共振成像数据来自 41 名有自杀行为的重度抑郁症（MDD）患者（sMDD，男/女：12/29）、44 名无自杀行为的重度抑郁症患者（nMDD，男/女：13/32）和 52 名健康对照组（HC，男/女：17/35）。研究人员使用青年躁狂量表、汉密尔顿抑郁量表、哥伦比亚自杀量表和自杀意念量表来评估情绪状态以及自杀意念和行为。研究还测定了低频波动幅度（ALFF）、区域同质性（ReHo）和奖赏网络中 11 个感兴趣区（ROIs）的功能连接性：结果：nMDD 组 vmPFC 的 ALFF 值明显低于 HC 组（p = 0.031）。与 HC 组相比，nMDD 组 lVS 的 ReHo 值较低，但 vmPFC 的 ReHo 值较高 (P = 0.018 和 0.025)。与 nMDD 组相比，sMDD 组 AC 与 vmPFC、lVS、rVS 和 vmPFC 的功能连接性增加（P = 0.038、0.034、0.006，分别为 0.038、0.034、0.006）：结论：在 MDD 组中发现了奖赏网络的局部和功能连接异常。结论：在 MDD 组中发现了奖赏网络的局部和功能连接异常，但只有在 sMDD 组中发现了功能连接的增加。

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来源期刊

Brain Topography 医学-临床神经学

CiteScore

4.70

自引率

7.40%

发文量

审稿时长

3 months

期刊介绍： Brain Topography publishes clinical and basic research on cognitive neuroscience and functional neurophysiology using the full range of imaging techniques including EEG, MEG, fMRI, TMS, diffusion imaging, spectroscopy, intracranial recordings, lesion studies, and related methods. Submissions combining multiple techniques are particularly encouraged, as well as reports of new and innovative methodologies.