The diagnostic value of cognitive assessment indicators for mild cognitive impairment (MCI).

IF 1.5 4区心理学 Q4 CLINICAL NEUROLOGY

Applied Neuropsychology-Adult Pub Date : 2025-11-01 Epub Date: 2024-02-05 DOI:10.1080/23279095.2024.2306144

Keyan Han, Wei Liang, Hao Geng, Xinyang Jing, Xuemeng Wang, Yaxin Huo, Wei Li, Anqi Huang, Cuixia An

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引用次数: 0

Abstract

Objective: This study aims to evaluate and analyze the standard diagnostic methods for mild cognitive impairment (MCI).

Methods: This study used a prospective case-control study to examine baseline data and diagnostic indicators in a population of elderly with MCI. Based on different cognitive abilities, this study divided MCI and healthy control groups. The diagnostic indicators included CDT, MOCA, MMSE, PSQI, MBI, DST, HAMD, AD-related blood markers, and olfactory testing. The diagnostic value of each indicator was done using the ROC curve.

Results: This study included 240 adult participants, 135 in the health group and 105 in the MCI group. A comparison of baseline data revealed statistically significant differences between the two groups regarding age, blood glucose, MMSE, CTD, MOCA, ability to perform daily living, AD-related blood indices and olfactory tests (all p < 0.05). Logistic regression analysis statistically showed that age, MOCA, and CDT were independent diagnostic factors for MCI (all p < 0.05). Combining these three indicators has the best diagnostic specificity (92.54%). AD-related blood and olfactory tests indices had only moderate diagnostic values (AUC: 0.7-0.8).

Conclusion: Age, MOCA, and CDT are good indicators for diagnosing early-stage MCI. AD-related blood indices and olfactory tests can serve as valuable adjuncts in diagnosing MCI.

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轻度认知障碍（MCI）认知评估指标的诊断价值。

目的：本研究旨在评估和分析轻度认知障碍（MCI）的标准诊断方法：本研究旨在评估和分析轻度认知障碍（MCI）的标准诊断方法：本研究采用前瞻性病例对照研究法，对患有 MCI 的老年人群的基线数据和诊断指标进行检查。根据不同的认知能力，该研究划分了 MCI 组和健康对照组。诊断指标包括 CDT、MOCA、MMSE、PSQI、MBI、DST、HAMD、AD 相关血液标记物和嗅觉测试。每项指标的诊断价值均采用ROC曲线进行计算：这项研究包括 240 名成年参与者，其中 135 人属于健康组，105 人属于 MCI 组。对基线数据进行比较后发现，两组在年龄、血糖、MMSE、CTD、MOCA、日常生活能力、AD 相关血液指数和嗅觉测试等方面存在显著的统计学差异（均为 p p 结论：年龄、MMSE、CTD、MOCA、日常生活能力、AD 相关血液指数和嗅觉测试等方面存在显著的统计学差异：年龄、MOCA 和 CDT 是诊断早期 MCI 的良好指标。与注意力缺失症相关的血液指数和嗅觉测试可作为诊断 MCI 的重要辅助指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Applied Neuropsychology-Adult CLINICAL NEUROLOGY-PSYCHOLOGY

CiteScore

4.50

自引率

11.80%

发文量

134

期刊介绍： pplied Neuropsychology-Adult publishes clinical neuropsychological articles concerning assessment, brain functioning and neuroimaging, neuropsychological treatment, and rehabilitation in adults. Full-length articles and brief communications are included. Case studies of adult patients carefully assessing the nature, course, or treatment of clinical neuropsychological dysfunctions in the context of scientific literature, are suitable. Review manuscripts addressing critical issues are encouraged. Preference is given to papers of clinical relevance to others in the field. All submitted manuscripts are subject to initial appraisal by the Editor-in-Chief, and, if found suitable for further considerations are peer reviewed by independent, anonymous expert referees. All peer review is single-blind and submission is online via ScholarOne Manuscripts.