Advancing Point-of-Care Applications with Droplet Microfluidics: From Single-Cell to Multicellular Analysis.

IF 12.8 1区 工程技术 Q1 ENGINEERING, BIOMEDICAL
Christina Sharkey, Rachel White, Michael Finocchiaro, Judene Thomas, Jose Estevam, Tania Konry
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引用次数: 0

Abstract

Recent advances in single-cell and multicellular microfluidics technology have provided powerful tools for studying cancer biology and immunology. The ability to create controlled microenvironments, perform high-throughput screenings, and monitor cellular interactions at the single-cell level has significantly advanced our understanding of tumor biology and immune responses. We discuss cutting-edge multicellular and single-cell microfluidic technologies and methodologies utilized to investigate cancer-immune cell interactions and assess the effectiveness of immunotherapies. We explore the advantages and limitations of the wide range of 3D spheroid and single-cell microfluidic models recently developed, highlighting the various approaches in device generation and applications in immunotherapy screening for potential opportunities for point-of-care approaches.

利用液滴微流控技术推进护理点应用:从单细胞到多细胞分析。
单细胞和多细胞微流控技术的最新进展为研究癌症生物学和免疫学提供了强大的工具。创建受控微环境、执行高通量筛选以及在单细胞水平监测细胞相互作用的能力大大促进了我们对肿瘤生物学和免疫反应的理解。我们将讨论最前沿的多细胞和单细胞微流控技术和方法,这些技术和方法可用于研究癌症与免疫细胞的相互作用并评估免疫疗法的有效性。我们探讨了最近开发的各种三维球形和单细胞微流体模型的优势和局限性,重点介绍了设备生成的各种方法以及在免疫疗法筛查中的应用,为护理点方法提供了潜在机会。生物医学工程年度综述》第 26 卷的最终在线出版日期预计为 2024 年 5 月。修订后的预计日期请参见 http://www.annualreviews.org/page/journal/pubdates。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annual Review of Biomedical Engineering
Annual Review of Biomedical Engineering 工程技术-工程:生物医学
CiteScore
18.80
自引率
0.00%
发文量
14
期刊介绍: Since 1999, the Annual Review of Biomedical Engineering has been capturing major advancements in the expansive realm of biomedical engineering. Encompassing biomechanics, biomaterials, computational genomics and proteomics, tissue engineering, biomonitoring, healthcare engineering, drug delivery, bioelectrical engineering, biochemical engineering, and biomedical imaging, the journal remains a vital resource. The current volume has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license.
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