High Mobility Group Box 1 Gene Polymorphism and Serum High Mobility Group Box 1, Interleukin 1 Beta, and Alpha-Klotho Crosstalk in Severe COVID-19 Patients.

IF 2.9 4区医学 Q3 IMMUNOLOGY

Immunological Investigations Pub Date : 2024-04-01 Epub Date: 2024-02-06 DOI:10.1080/08820139.2023.2299680

Maha Houssen, Rasha El-Mahdy, Nouran E Samra, Yousra Tera, Kamel Nayera Mostafa, Manal M El-Desoky, Fatma Azzahraa Hisham, Asem A Hewidy, Rehab A Elmorsey, Hala Samaha, Rasha Mahmoud, Mona S Abdelhafez

{"title":"High Mobility Group Box 1 Gene Polymorphism and Serum High Mobility Group Box 1, Interleukin 1 Beta, and Alpha-Klotho Crosstalk in Severe COVID-19 Patients.","authors":"Maha Houssen, Rasha El-Mahdy, Nouran E Samra, Yousra Tera, Kamel Nayera Mostafa, Manal M El-Desoky, Fatma Azzahraa Hisham, Asem A Hewidy, Rehab A Elmorsey, Hala Samaha, Rasha Mahmoud, Mona S Abdelhafez","doi":"10.1080/08820139.2023.2299680","DOIUrl":null,"url":null,"abstract":"Aim: To evaluate the serum levels of HMGB1, IL1β, and α-klotho in COVID-19 patients with different disease severity, investigate their association with clinicopathological parameters, and to assess HMGB1 rs1045411 polymorphism and its relation with clinical severity.Methods: 120 COVID-19 patients (89 critically ill, 15 severe, and 16 moderately severe) along with 80 healthy control were enrolled.The serum levels of HMGB1,IL1β, and α-klotho were determined by ELISA. The HMGB1 rs1045411 polymorphism was detected by RT- PCR.Results: The serum levels of HMGB1, IL1β, and α-klotho were significantly higher in critically ill COVID-19 patients compared to other groups. The HMGB1rs1045411 polymorphism revealed a significant decrease in the percentage of T/T genotypes in COVID-19 patients compared to controls. The (ROC) analysis showed moderate diagnostic potential for serum HMGB1, IL1β, and α-klotho.Conclusion: The serum HMGB1, IL1β, and α-klotho may be severity markers and promising therapeutic targets for COVID-19 patients.","PeriodicalId":13387,"journal":{"name":"Immunological Investigations","volume":" ","pages":"450-463"},"PeriodicalIF":2.9000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Immunological Investigations","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/08820139.2023.2299680","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/2/6 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Aim: To evaluate the serum levels of HMGB1, IL1β, and α-klotho in COVID-19 patients with different disease severity, investigate their association with clinicopathological parameters, and to assess HMGB1 rs1045411 polymorphism and its relation with clinical severity.

Methods: 120 COVID-19 patients (89 critically ill, 15 severe, and 16 moderately severe) along with 80 healthy control were enrolled.The serum levels of HMGB1,IL1β, and α-klotho were determined by ELISA. The HMGB1 rs1045411 polymorphism was detected by RT- PCR.

Results: The serum levels of HMGB1, IL1β, and α-klotho were significantly higher in critically ill COVID-19 patients compared to other groups. The HMGB1rs1045411 polymorphism revealed a significant decrease in the percentage of T/T genotypes in COVID-19 patients compared to controls. The (ROC) analysis showed moderate diagnostic potential for serum HMGB1, IL1β, and α-klotho.

Conclusion: The serum HMGB1, IL1β, and α-klotho may be severity markers and promising therapeutic targets for COVID-19 patients.

查看原文本刊更多论文

严重 COVID-19 患者的高迁移率组 Box 1 基因多态性与血清高迁移率组 Box 1、白细胞介素 1 Beta 和 Alpha-Klotho 相互关系

目的：评估不同病情严重程度的COVID-19患者血清中HMGB1、IL1β和α-klotho的水平，研究其与临床病理参数的关系，并评估HMGB1 rs1045411多态性及其与临床严重程度的关系。方法：纳入120例COVID-19患者（89例重症患者、15例重度患者和16例中度患者）和80例健康对照。通过 RT- PCR 检测 HMGB1 rs1045411 多态性：结果：COVID-19重症患者血清中HMGB1、IL1β和α-klotho水平明显高于其他组。HMGB1rs1045411多态性显示，与对照组相比，COVID-19患者的T/T基因型比例明显下降。ROC分析显示，血清HMGB1、IL1β和α-klotho具有中等诊断潜力：结论：血清HMGB1、IL1β和α-klotho可能是COVID-19患者的严重程度标志物和有希望的治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Immunological Investigations 医学-免疫学

CiteScore

5.50

自引率

7.10%

发文量

审稿时长

3 months

期刊介绍： Disseminating immunological developments on a worldwide basis, Immunological Investigations encompasses all facets of fundamental and applied immunology, including immunohematology and the study of allergies. This journal provides information presented in the form of original research articles and book reviews, giving a truly in-depth examination of the latest advances in molecular and cellular immunology.