Technological Advancement and Trend in Selective Bioanalytical Sample Extraction through State of the Art 3-D Printing Techniques Aiming 'Sorbent Customization as per need'.
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引用次数: 0
Abstract
The inherent complexity of biological matrices and presence of several interfering substances in biological samples make them unsuitable for direct analysis. An effective sample preparation technique assists in analyte enrichment, improving selectivity and sensitivity of bioanalytical method. Because of several key benefits of employing 3D printed sorbent in sample extraction, it has recently gained popularity across a variety of industries. Applications for 3D printing in the field of bioanalytical research have grown recently, particularly in the areas of miniaturization, (bio)sensing, sample preparation, and separation sciences. Due to the high expense of the solid phase microextraction cartridge, researcher approaches in-lab production of sorbent material for the extraction of analyte from biological samples. Owing to its distinct advantages such as low costs, automation capabilities, capacity to produce products in a variety of shapes, and reduction of tedious steps of sample preparation, 3D printed sorbents are gaining increased attention in the field of bioanalysis. It is also reported to offer high selectivity and assist in achieving a much lower limit of detection. In this review, we have discussed current advancements in different types of 3D printed sorbents, production methods, and their applications in the field of bioanalytical sample preparation.
生物基质本身的复杂性以及生物样本中多种干扰物质的存在,使其不适合直接进行分析。有效的样品制备技术有助于富集分析物,提高生物分析方法的选择性和灵敏度。由于三维打印吸附剂在样品提取中的几大优势,它最近在各行各业都受到了欢迎。最近,3D 打印在生物分析研究领域的应用越来越多,尤其是在微型化、(生物)传感、样品制备和分离科学领域。由于固相微萃取盒的价格昂贵,研究人员采用了在实验室内生产吸附剂材料的方法从生物样品中萃取分析物。由于 3D 打印吸附剂具有成本低、自动化能力强、可生产各种形状的产品、减少繁琐的样品制备步骤等显著优势,因此在生物分析领域越来越受到关注。据报道,3D 打印吸附剂还具有高选择性,有助于实现更低的检测限。在本综述中,我们讨论了不同类型 3D 打印吸附剂的当前进展、生产方法及其在生物分析样品制备领域的应用。
期刊介绍:
Critical Reviews in Analytical Chemistry continues to be a dependable resource for both the expert and the student by providing in-depth, scholarly, insightful reviews of important topics within the discipline of analytical chemistry and related measurement sciences. The journal exclusively publishes review articles that illuminate the underlying science, that evaluate the field''s status by putting recent developments into proper perspective and context, and that speculate on possible future developments. A limited number of articles are of a "tutorial" format written by experts for scientists seeking introduction or clarification in a new area.
This journal serves as a forum for linking various underlying components in broad and interdisciplinary means, while maintaining balance between applied and fundamental research. Topics we are interested in receiving reviews on are the following:
· chemical analysis;
· instrumentation;
· chemometrics;
· analytical biochemistry;
· medicinal analysis;
· forensics;
· environmental sciences;
· applied physics;
· and material science.