Imbalance Between Angiotensin II and Kallikrein in Patients With ST-Segment Elevation Myocardial Infarction: A Case-Control Emergency Room Study.

IF 2.2 3区医学 Q2 PERIPHERAL VASCULAR DISEASE

Angiology Pub Date : 2025-07-01 Epub Date: 2024-02-05 DOI:10.1177/00033197241232165

Shuhong Dai, Bo Yin, Haiming Wang, Xiaowei Zhang

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引用次数: 0

Abstract

The present study aimed to investigate the balance between angiotensin II (Ang-II) and kallikrein (KLK1) in the pathogenesis of ST-segment elevation acute myocardial infarction (STEMI). The study included a total of 261 participants: 151 STEMI patients and 110 individuals with normal coronary arteries. The plasma levels of Ang-II and KLK1 were measured using enzyme-linked immunosorbent assays (ELISA). Multivariate logistic regression analysis indicated that the plasma levels of Ang-II, KLK1 and the ratio of Ang-II and KLK1 (Ang-II/KLK1) independently correlated with the presence of STEMI. Furthermore, we found independent associations between STEMI and smoking, cholesterol (CHO), high-density lipoprotein cholesterol (HDL-c), as well as age. The ratio of Ang-II/KLK1 correlated with the plasma level of the inflammatory cytokine, interleukin-6 (IL-6). Both Ang-II and KLK1 levels are significantly elevated in patients with STEMI. An increased Ang-II/KLK1 ratio may result in the over-activation of Ang-II and exacerbate the progression of STEMI(P = .046). In conclusion, we have demonstrated, for the first time, an Ang-II and KLK1 imbalance in patients with STEMI.

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ST 段抬高型心肌梗死患者血管紧张素 II 与 Kallikrein 之间的失衡：急诊室病例对照研究》。

本研究旨在探讨血管紧张素 II（Ang-II）和allikrein（KLK1）在 ST 段抬高型急性心肌梗死（STEMI）发病机制中的平衡关系。该研究共纳入了 261 名参与者：其中包括 151 名 STEMI 患者和 110 名冠状动脉正常者。研究人员使用酶联免疫吸附试验（ELISA）测定了血浆中 Ang-II 和 KLK1 的水平。多变量逻辑回归分析表明，血浆中 Ang-II、KLK1 的水平以及 Ang-II 和 KLK1 的比率（Ang-II/KLK1）与 STEMI 的存在有独立的相关性。此外，我们还发现 STEMI 与吸烟、胆固醇（CHO）、高密度脂蛋白胆固醇（HDL-c）以及年龄之间存在独立关联。Ang-II/KLK1的比值与血浆中炎症细胞因子白细胞介素-6（IL-6）的水平相关。STEMI 患者的 Ang-II 和 KLK1 水平均显著升高。Ang-II/KLK1 比值升高可能导致 Ang-II 过度激活，加剧 STEMI 的进展（P = .046）。总之，我们首次证明了 STEMI 患者体内 Ang-II 和 KLK1 的失衡。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Angiology 医学-外周血管病

CiteScore

5.50

自引率

14.30%

发文量

180

审稿时长

6-12 weeks

期刊介绍： A presentation of original, peer-reviewed original articles, review and case reports relative to all phases of all vascular diseases, Angiology (ANG) offers more than a typical cardiology journal. With approximately 1000 pages per year covering diagnostic methods, therapeutic approaches, and clinical and laboratory research, ANG is among the most informative publications in the field of peripheral vascular and cardiovascular diseases. This journal is a member of the Committee on Publication Ethics (COPE). Average time from submission to first decision: 13 days