Function of NAD metabolism in white adipose tissue: lessons from mouse models.

IF 3.5 4区生物学 Q2 ENDOCRINOLOGY & METABOLISM

Adipocyte Pub Date : 2024-12-01 Epub Date: 2024-02-15 DOI:10.1080/21623945.2024.2313297

So Young Kwon, Yoon Jung Park

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引用次数: 0

Abstract

Nicotinamide Adenine Dinucleotide (NAD) is an endogenous substance in redox reactions and regulates various functions in metabolism. NAD and its precursors are known for their anti-ageing and anti-obesity properties and are mainly active in the liver and muscle. Boosting NAD+ through supplementation with the precursors, such as nicotinamide mononucleotide (NMN) or nicotinamide riboside (NR), enhances insulin sensitivity and circadian rhythm in the liver, and improves mitochondrial function in the muscle. Recent evidence has revealed that the adipose tissue could be another direct target of NAD supplementation by attenuating inflammation and fat accumulation. Moreover, murine studies with genetically modified models demonstrated that nicotinamide phosphoribosyltransferase (NAMPT), a NAD regulatory enzyme that synthesizes NMN, played a critical role in lipogenesis and lipolysis in an adipocyte-specific manner. The tissue-specific effects of NAD+ metabolic pathways indicate a potential of the NAD precursors to control metabolic stress particularly via focusing on adipose tissue. Therefore, this narrative review raises an importance of NAD metabolism in white adipose tissue (WAT) through a variety of studies using different mouse models.

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白色脂肪组织中 NAD 代谢的功能：小鼠模型的启示。

烟酰胺腺嘌呤二核苷酸（NAD）是氧化还原反应中的一种内源性物质，调节新陈代谢中的各种功能。NAD 及其前体具有抗衰老和抗肥胖的功效，主要活跃在肝脏和肌肉中。通过补充前体物质（如烟酰胺单核苷酸（NMN）或烟酰胺核苷酸（NR））来提高 NAD+，可增强肝脏对胰岛素的敏感性和昼夜节律，并改善肌肉中线粒体的功能。最近的证据显示，脂肪组织可能是补充 NAD 的另一个直接目标，因为它可以减轻炎症和脂肪堆积。此外，利用转基因模型进行的小鼠研究表明，烟酰胺磷酸核糖转移酶（NAMPT）是一种合成 NMN 的 NAD 调节酶，它以脂肪细胞特异性的方式在脂肪生成和脂肪分解中发挥着关键作用。NAD+ 代谢途径对组织的特异性影响表明，NAD 前体具有控制代谢压力的潜力，尤其是通过关注脂肪组织。因此，本综述通过使用不同小鼠模型的各种研究，提出了 NAD 代谢在白色脂肪组织（WAT）中的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Adipocyte Medicine-Histology

CiteScore

6.50

自引率

3.00%

发文量

审稿时长

32 weeks

期刊介绍： Adipocyte recognizes that the adipose tissue is the largest endocrine organ in the body, and explores the link between dysfunctional adipose tissue and the growing number of chronic diseases including diabetes, hypertension, cardiovascular disease and cancer. Historically, the primary function of the adipose tissue was limited to energy storage and thermoregulation. However, a plethora of research over the past 3 decades has recognized the dynamic role of the adipose tissue and its contribution to a variety of physiological processes including reproduction, angiogenesis, apoptosis, inflammation, blood pressure, coagulation, fibrinolysis, immunity and general metabolic homeostasis. The field of Adipose Tissue research has grown tremendously, and Adipocyte is the first international peer-reviewed journal of its kind providing a multi-disciplinary forum for research focusing exclusively on all aspects of adipose tissue physiology and pathophysiology. Adipocyte accepts high-profile submissions in basic, translational and clinical research.