Application of the Crystal Structure of the SARS-CoV-2 Spike Protein for the Development of a Peptide Vaccine against Virus

IF 0.6 4区材料科学 Q4 CRYSTALLOGRAPHY

Crystallography Reports Pub Date : 2024-02-05 DOI:10.1134/s1063774523601065

A. S. Ivanovsky, I. A. Kolesnikov, Yu. V. Kordonskaya, A. V. Ermakov, M. A. Marchenkova, V. I. Timofeev, Yu. V. Pisarevsky, Yu. A. Dyakova, M. V. Kovalchuk

引用次数: 0

Abstract

Based on the spike protein of the SARS-CoV-2 virus, a protein capable of causing an immune answer has been predicted. The protein stability in solution is confirmed by the molecular dynamics simulation. Immunomodulation has shown that this protein causes an immune reaction and, correspondingly, may serve a vaccine prototype.

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应用 SARS-CoV-2 Spike 蛋白的晶体结构开发抗病毒肽疫苗

摘要以 SARS-CoV-2 病毒的尖峰蛋白为基础，预测了一种能够引起免疫应答的蛋白质。分子动力学模拟证实了这种蛋白质在溶液中的稳定性。免疫调节表明，这种蛋白质能引起免疫反应，因此可以作为疫苗的原型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Crystallography Reports 化学-晶体学

CiteScore

1.10

自引率

28.60%

发文量

审稿时长

4-8 weeks

期刊介绍： Crystallography Reports is a journal that publishes original articles short communications, and reviews on various aspects of crystallography: diffraction and scattering of X-rays, electrons, and neutrons, determination of crystal structure of inorganic and organic substances, including proteins and other biological substances; UV-VIS and IR spectroscopy; growth, imperfect structure and physical properties of crystals; thin films, liquid crystals, nanomaterials, partially disordered systems, and the methods of studies.

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