Zinc-Boron Complex-Based Dietary Supplements for Longevity and Healthy Life.

Current health sciences journal Pub Date : 2023-07-01 Epub Date: 2023-09-30 DOI:10.12865/CHSJ.49.03.10
Andrei Biţă, Ion Romulus Scorei, Tudor Adrian Bălşeanu, Gabriela Rău, Maria Viorica Ciocîlteu, George Dan Mogoşanu
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Abstract

The nutritional role of zinc (Zn) and boron (B) in the plant-animal-human food chain is highly topical worldwide research. Our data indicated that Zn-B complex (ZBC)-based dietary supplements can be used as stable non-toxic formulations, with high intestinal absorption rate, inducing alpha2-macroglobulin (A2M) expression for longevity and healthy life. ZBC is metabolized by hydrolysis, mainly at the absorption site (intestinal level), and most of it is excreted in the urine. Within seven hours from the administration in mice, almost the entire amount of orally absorbed ZBC is eliminated in a metabolized form. The highest amount of A2M protein in mouse liver was determined by immunoabsorbance assay in the chronic experiment (1000mg/kg of ZBC), followed by the subchronic experiment (at the same dose of ZBC), and by the acute experiment (5000mg/kg of ZBC).

基于锌硼复合物的膳食补充剂,促进长寿和健康生活。
锌(Zn)和硼(B)在植物-动物-人类食物链中的营养作用是全球研究的热点。我们的数据表明,以锌-硼复合物(ZBC)为基础的膳食补充剂可用作稳定无毒的制剂,具有较高的肠道吸收率,可诱导α2-巨球蛋白(A2M)的表达,从而促进健康长寿。ZBC 主要在吸收部位(肠道水平)水解代谢,大部分随尿液排出体外。小鼠在服药后 7 小时内,口服吸收的 ZBC 几乎全部以代谢形式排出体外。通过免疫吸附测定,小鼠肝脏中的 A2M 蛋白含量最高的是慢性实验(每千克 ZBC 含量为 1000 毫克),其次是亚慢性实验(ZBC 剂量相同)和急性实验(每千克 ZBC 含量为 5000 毫克)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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