Serum level of lactadherin (MFGE8) in inflamatory bowel disease.

Q3 Medicine

Folia medica Cracoviensia Pub Date : 2023-10-30 DOI:10.24425/fmc.2023.147212

Kamil Kozioł, Danuta Owczarek, Dorota Cibor, Małgorzata Zwolińska-Wcisło

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引用次数: 0

Abstract

Objective: Evaluation of serum lactadherin level, its correlation with disease activity and certain biochemical parameters in IBD patients.

Methods: The study involved adult IBD patients, comprising 50 with ulcerative colitis (UC), 68 with Crohn's disease (CD), and 29 healthy controls.

Results: The MFGE8 median concentration was significantly higher in UC versus controls (1914.54 vs. 1392.21; p = 0.017), but not in CD. The median MFGE8 levels in UC and CD patient groups didn't significantly differ. There was a significant inverse correlation between MFGE8 and CRP (r = -0.283; p = 0.044) and fibrinogen (r = -0.362, p = 0.017) in UC. In active UC, MFGE8 median concentration was higher versus controls (1974.36 vs. 1392.21; p = 0.04) and negatively correlated with CRP (r = -0.482; p = 0.005), WBC (r = -0.391; p = 0.027), and fibrinogen (r = -0.473; p = 0.015). Inactive UC showed negative correlation only with fibrinogen (r = -0.567; p = 0.018). No correlations were found with disease activity measured using appropriate scales, age, BMI, or gender.

Conclusions: Active UC patients show higher MFGE8 levels. These increase inversely with inflammatory markers (CRP, WBC, fibrinogen) in active UC, but not in CD.

查看原文本刊更多论文

炎症性肠病的血清乳粘连素（MFGE8）水平。

目的：评估 IBD 患者血清乳黏蛋白水平及其与疾病活动和某些生化指标的相关性：评估 IBD 患者血清乳黏蛋白水平及其与疾病活动性和某些生化指标的相关性：研究对象为成年 IBD 患者，包括 50 名溃疡性结肠炎（UC）患者、68 名克罗恩病（CD）患者和 29 名健康对照者：UC患者的MFGE8浓度中位数明显高于对照组（1914.54 vs. 1392.21; p = 0.017），但CD患者的MFGE8浓度中位数并不高。UC患者组和CD患者组的MFGE8中位数水平没有明显差异。在 UC 中，MFGE8 与 CRP（r = -0.283；p = 0.044）和纤维蛋白原（r = -0.362，p = 0.017）之间存在明显的反相关性。在活动性 UC 中，MFGE8 中位浓度高于对照组（1974.36 对 1392.21；p = 0.04），并与 CRP（r = -0.482；p = 0.005）、白细胞（r = -0.391；p = 0.027）和纤维蛋白原（r = -0.473；p = 0.015）呈负相关。非活动性 UC 仅与纤维蛋白原呈负相关（r = -0.567；p = 0.018）。使用适当的量表测量疾病活动度、年龄、体重指数或性别均未发现相关性：结论：活动性 UC 患者的 MFGE8 水平较高。结论：活动性 UC 患者的 MFGE8 水平较高，与活动性 UC 患者的炎症指标（CRP、白细胞、纤维蛋白原）呈反比增加，但与 CD 患者的情况不同。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Folia medica Cracoviensia Medicine-Medicine (all)

CiteScore

1.20

自引率

0.00%

发文量