Combating Aminoglycoside Resistance: From Structural and Functional Characterisation to Therapeutic Challenges with RKAAT.

IF 1.9 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current protein & peptide science Pub Date : 2024-01-01 DOI:10.2174/0113892037278814231226104509

Sarah Oluwatobi Otun, Richard Graca, Ikechukwu Achilonu

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Abstract

A comprehensive knowledge of aminoglycoside-modifying enzymes (AMEs) and their role in bacterial resistance mechanisms is urgently required due to the rising incidence of antibiotic resistance, particularly in Klebsiella pneumoniae infections. This study explores the essential features of AMEs, including their structural and functional properties, the processes by which they contribute to antibiotic resistance, and the therapeutic importance of aminoglycosides. The study primarily examines the Recombinant Klebsiella pneumoniae Aminoglycoside Adenylyl Transferase (RKAAT), particularly emphasizing its biophysical characteristics and the sorts of resistance it imparts. Furthermore, this study examines the challenges presented by RKAAT-mediated resistance, an evaluation of treatment methods and constraints, and options for controlling infection. The analysis provides a prospective outlook on strategies to address and reduce antibiotic resistance. This extensive investigation seeks to provide vital insights into the continuing fight against bacterial resistance, directing future research efforts and medicinal approaches.

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抗击氨基糖苷类药物耐药性：从 RKAAT 的结构和功能特性到治疗挑战。

由于抗生素耐药性的发生率不断上升，尤其是在肺炎克雷伯氏菌感染中，因此迫切需要全面了解氨基糖苷修饰酶（AMEs）及其在细菌耐药性机制中的作用。本研究探讨了 AMEs 的基本特征，包括其结构和功能特性、导致抗生素耐药性的过程以及氨基糖苷类药物的治疗重要性。本研究主要探讨了重组肺炎克雷伯菌氨基糖苷腺苷酸转移酶（RKAAT），特别强调了它的生物物理特性及其产生的耐药性。此外，本研究还探讨了 RKAAT 介导的耐药性所带来的挑战、对治疗方法和限制因素的评估以及控制感染的方案。分析为解决和减少抗生素耐药性的策略提供了前瞻性展望。这项广泛的调查旨在为持续对抗细菌耐药性提供重要见解，指导未来的研究工作和医疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current protein & peptide science 生物-生化与分子生物学

CiteScore

5.20

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Current Protein & Peptide Science publishes full-length/mini review articles on specific aspects involving proteins, peptides, and interactions between the enzymes, the binding interactions of hormones and their receptors; the properties of transcription factors and other molecules that regulate gene expression; the reactions leading to the immune response; the process of signal transduction; the structure and function of proteins involved in the cytoskeleton and molecular motors; the properties of membrane channels and transporters; and the generation and storage of metabolic energy. In addition, reviews of experimental studies of protein folding and design are given special emphasis. Manuscripts submitted to Current Protein and Peptide Science should cover a field by discussing research from the leading laboratories in a field and should pose questions for future studies. Original papers, research articles and letter articles/short communications are not considered for publication in Current Protein & Peptide Science.