The role of NPY signaling pathway in diagnosis, prognosis and treatment of stroke

IF 2.5 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Neuropeptides Pub Date : 2024-02-04 DOI:10.1016/j.npep.2024.102412

Taotao Jiang , Ting Zheng , Rundong Li , Jingjing Sun , Xiaoqing Luan , Manxia Wang

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Abstract

Neuropeptide Y (NPY), an extensively distributed neurotransmitter within the central nervous system (CNS), was initially detected and isolated from the brain of a pig in 1982. By binding to its G protein-coupled receptors, NPY regulates immune responses and contributes to the pathogenesis of numerous inflammatory diseases. The hippocampus contained the maximum concentration in the CNS, with the cerebral cortex, hypothalamus, thalamus, brainstem, and cerebellum following suit. This arrangement suggests that the substance has a specific function within the CNS. More and more studies have shown that NPY is involved in the physiological and pathological mechanism of stroke, and its serum concentration can be one of the specific biomarkers of stroke and related complications because of its high activity, broad and complex effects. By summarizing relevant literature, this article aims to gain a thorough understanding of the potential clinical applications of NPY in the treatment of stroke, identification of stroke and its related complications, and assessment of prognosis.

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NPY 信号通路在脑卒中诊断、预后和治疗中的作用

神经肽 Y（Neuropeptide Y，NPY）是一种广泛分布于中枢神经系统（CNS）的神经递质，1982 年首次从猪脑中发现并分离出来。通过与其 G 蛋白偶联受体结合，NPY 可调节免疫反应，并参与多种炎症性疾病的发病机制。在中枢神经系统中，海马体的浓度最高，大脑皮层、下丘脑、丘脑、脑干和小脑的浓度紧随其后。这种排列表明，这种物质在中枢神经系统中具有特定的功能。越来越多的研究表明，NPY 参与了脑卒中的生理和病理机制，由于其活性高、作用广泛而复杂，其血清浓度可作为脑卒中及相关并发症的特异性生物标志物之一。本文通过总结相关文献，旨在全面了解 NPY 在治疗脑卒中、识别脑卒中及其相关并发症、评估预后等方面的潜在临床应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropeptides 医学-内分泌学与代谢

CiteScore

5.40

自引率

6.90%

发文量

审稿时长

>12 weeks

期刊介绍： The aim of Neuropeptides is the rapid publication of original research and review articles, dealing with the structure, distribution, actions and functions of peptides in the central and peripheral nervous systems. The explosion of research activity in this field has led to the identification of numerous naturally occurring endogenous peptides which act as neurotransmitters, neuromodulators, or trophic factors, to mediate nervous system functions. Increasing numbers of non-peptide ligands of neuropeptide receptors have been developed, which act as agonists or antagonists in peptidergic systems. The journal provides a unique opportunity of integrating the many disciplines involved in all neuropeptide research. The journal publishes articles on all aspects of the neuropeptide field, with particular emphasis on gene regulation of peptide expression, peptide receptor subtypes, transgenic and knockout mice with mutations in genes for neuropeptides and peptide receptors, neuroanatomy, physiology, behaviour, neurotrophic factors, preclinical drug evaluation, clinical studies, and clinical trials.