Prevalence of Renal Neoplasia in Autosomal Dominant Polycystic Kidney Disease: Systematic Review and Meta-Analysis.

IF 2.3 4区 医学 Q2 UROLOGY & NEPHROLOGY
Nephron Pub Date : 2024-01-01 Epub Date: 2024-02-01 DOI:10.1159/000536245
Anna M Drake, Jessica A Paynter, Arthur Yim, Jake A Tempo, Todd G Manning, Janelle Brennan, Kirby R Qin
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Abstract

Background: Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited condition; however, its relationship with renal cell carcinoma (RCC) remains unclear. This paper aims to establish the prevalence of RCC and its subtypes amongst ADPKD patients.

Methods: A database search was conducted to retrieve studies reporting RCC occurrence within ADPKD patients until July 2023. Key outcomes included number and subtype of RCC cases, and number of RCCs presenting incidentally. A random-effects meta-analysis was performed.

Results: Our search yielded 569 articles, 16 met the inclusion criteria. Nephrectomy specimens from 1,147 ADPKD patients were identified. Of studies reporting per-kidney results (n = 13), 73 RCCs were detected amongst 1,493 kidneys, equating to a per-kidney prevalence of 4.3% (95% CI, 3.1-5.7, I2 = 15.7%). 75 ADPKD patients were found to have RCC (75/1,147), resulting in a per-person prevalence of 5.7% (95% CI, 3.7-7.9, I2 = 40.3%) (n = 16). As 7 patients had bilateral disease, 82 RCCs were detected in total. Of these, 39 were clear cell RCC, 35 were papillary and 8 were other. As such, papillary RCCs made up 41.1% (95% CI, 25.9-56.9, I2 = 18.1%) of detected cancers. The majority of RCCs were detected incidentally (72.5% [95% CI, 43.7-95.1, I2 = 66.9%]).

Conclusion: ADPKD appears to be associated with the papillary RCC subtype. The clinical implications of these findings are unclear, however, may become apparent as outcomes and life expectancy amongst APDKD patients improve.

常染色体显性多囊肾病中肾肿瘤的患病率:系统回顾与元分析》。
背景:常染色体显性多囊肾(ADPKD)是一种常见的遗传性疾病,但它与肾细胞癌(RCC)的关系仍不清楚。本文旨在确定RCC及其亚型在ADPKD患者中的发病率:方法:通过数据库搜索,检索截至 2023 年 7 月报告 ADPKD 患者中发生 RCC 的研究。主要结果包括RCC病例的数量和亚型,以及偶然出现的RCC数量。我们进行了随机效应荟萃分析:结果:我们的研究共搜索到 569 篇文章,其中 16 篇符合纳入标准。确定了来自 1,147 名 ADPKD 患者的肾切除标本。在报告每个肾脏结果的研究中(n = 13),1,493个肾脏中检测出73个RCC,相当于每个肾脏的患病率为4.3%(95% CI,3.1-5.7,I2 = 15.7%)。75名ADPKD患者被发现患有RCC(75/1147),人均患病率为5.7%(95% CI,3.7至7.9,I2 = 40.3%)(n = 16)。由于7名患者患有双侧疾病,因此共检测出82颗RCC。其中,39例为透明细胞RCC,35例为乳头状RCC,8例为其他RCC。因此,乳头状RCC占检出癌症的41.1%(95% CI,25.9至56.9,I2 = 18.1%)。大多数RCC是偶然发现的(72.5% [95% CI, 43.7 to 95.1, I2 = 66.9%]):结论:ADPKD似乎与乳头状RCC亚型有关。结论:ADPKD似乎与乳头状RCC亚型有关。这些发现的临床意义尚不明确,但随着APDKD患者的预后和预期寿命的改善,其临床意义可能会变得明显。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Nephron
Nephron UROLOGY & NEPHROLOGY-
CiteScore
5.00
自引率
0.00%
发文量
80
期刊介绍: ''Nephron'' comprises three sections, which are each under the editorship of internationally recognized leaders and served by specialized Associate Editors. Apart from high-quality original research, ''Nephron'' publishes invited reviews/minireviews on up-to-date topics. Papers undergo an innovative and transparent peer review process encompassing a Presentation Report which assesses and summarizes the presentation of the paper in an unbiased and standardized way.
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