A Study to Identify and Analyze the Radiosensitivity of 4-Piperidinecarboxylic Acid Using Electron Paramagnetic Resonance Spectroscopy

IF 1.1 4区物理与天体物理 Q4 PHYSICS, ATOMIC, MOLECULAR & CHEMICAL

Applied Magnetic Resonance Pub Date : 2024-02-01 DOI:10.1007/s00723-024-01641-3

Kerem Sütçü

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Abstract

This study aims to investigate the spectroscopic, dosimetric, and stability properties of free radicals generated within 4-piperidinecarboxylic acid (4PCA) sample due to gamma irradiation within the 2–20 kGy range, utilizing electron paramagnetic resonance (EPR) spectroscopy. To achieve this goal, the EPR signals of the samples were studied in relation to microwave power, ranging from 0.01 to 50 mW, at room temperature. The investigation revealed that γ-irradiation induces the formation of –CH₂ĊCH₂CH₂– (radical I) and –ĊHN– (radical II) radicals within the 4PCA compound. Hyperfine structure constants and g values were also determined for the radicals. The optimal agreement between experimental and computed results within the dose range of 2–20 kGy was achieved using polynomial and linear functions. Experimental measurements were undertaken under varied temperature conditions (123–323 K) to study the dosimetric features of free radicals generated as a consequence of gamma irradiation. Furthermore, an investigation into the time dependency of signal intensity within the irradiated sample was conducted, with the objective of analyzing the long-term stability characteristics of the free radicals present.

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利用电子顺磁共振波谱鉴别和分析 4-哌啶甲酸辐射敏感性的研究

本研究旨在利用电子顺磁共振（EPR）光谱学，研究 2-20 kGy 范围内伽马辐照在 4-哌啶甲酸（4PCA）样品中产生的自由基的光谱、剂量测定和稳定性能。为了实现这一目标，我们在室温下研究了样品的 EPR 信号与 0.01 至 50 mW 微波功率的关系。研究发现，γ-辐照会在 4PCA 化合物中诱导形成 -CH2ĊCH2CH2-（自由基 I）和 -ĊHN-（自由基 II）自由基。此外，还测定了这些自由基的超细结构常数和 g 值。在 2-20 kGy 的剂量范围内，使用多项式和线性函数实现了实验结果与计算结果的最佳一致。在不同的温度条件（123-323 K）下进行了实验测量，以研究伽马辐照产生的自由基的剂量学特征。此外，还对辐照样品中信号强度的时间依赖性进行了研究，目的是分析存在的自由基的长期稳定性特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Applied Magnetic Resonance 物理-光谱学

CiteScore

1.90

自引率

10.00%

发文量

审稿时长

2.3 months

期刊介绍： Applied Magnetic Resonance provides an international forum for the application of magnetic resonance in physics, chemistry, biology, medicine, geochemistry, ecology, engineering, and related fields. The contents include articles with a strong emphasis on new applications, and on new experimental methods. Additional features include book reviews and Letters to the Editor.