Stress biomarker changes following a series of repeated static and dynamic apneas in non-divers

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-02-01 DOI:10.1016/j.resp.2024.104228

Antonis Elia , Matthew J. Barlow , Matthew J. Lees , Georgios Petri , Michail E. Keramidas

{"title":"Stress biomarker changes following a series of repeated static and dynamic apneas in non-divers","authors":"Antonis Elia , Matthew J. Barlow , Matthew J. Lees , Georgios Petri , Michail E. Keramidas","doi":"10.1016/j.resp.2024.104228","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><p>This study examined the magnitude of physiological strain imposed by repeated maximal static and dynamic apneas through assessing a panel of stress-related biomarkers.</p></div><div><h3>Methods</h3><p>Eleven healthy men performed on three separate occasions (≥72-h apart): a series of five repeated maximal (i) static (STA) or (ii) dynamic apneas (DYN) or (iii) a static eupneic protocol (CTL). Venous blood samples were drawn at 30, 90, and 180-min after each protocol to determine ischaemia modified albumin (IMA), neuron-specific enolase (NSE), myoglobin, and high sensitivity cardiac troponin T (hscTnT) concentrations.</p></div><div><h3>Results</h3><p>IMA was elevated after the apnoeic interventions (STA,+86%;DYN,+332%,p ≤ 0.047) but not CTL (p = 0.385). Myoglobin was higher than baseline (23.6 ± 3.9 ng/mL) 30-min post DYN (+70%,38.8 ± 13.3 ng/mL,p = 0.030). A greater myoglobin release was recorded in DYN compared with STA and CTL (p ≤ 0.035). No changes were observed in NSE (p = 0.207) or hscTnT (p = 0.274).</p></div><div><h3>Conclusions</h3><p>Five repeated maximal DYN led to a greater muscle injury compared with STA but neither elicited myocardial injury or neuronal-parenchymal damage.</p></div>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1569904824000211/pdfft?md5=ef817c12d93152298a2659dd8a435fc9&pid=1-s2.0-S1569904824000211-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1569904824000211","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose

This study examined the magnitude of physiological strain imposed by repeated maximal static and dynamic apneas through assessing a panel of stress-related biomarkers.

Methods

Eleven healthy men performed on three separate occasions (≥72-h apart): a series of five repeated maximal (i) static (STA) or (ii) dynamic apneas (DYN) or (iii) a static eupneic protocol (CTL). Venous blood samples were drawn at 30, 90, and 180-min after each protocol to determine ischaemia modified albumin (IMA), neuron-specific enolase (NSE), myoglobin, and high sensitivity cardiac troponin T (hscTnT) concentrations.

Results

IMA was elevated after the apnoeic interventions (STA,+86%;DYN,+332%,p ≤ 0.047) but not CTL (p = 0.385). Myoglobin was higher than baseline (23.6 ± 3.9 ng/mL) 30-min post DYN (+70%,38.8 ± 13.3 ng/mL,p = 0.030). A greater myoglobin release was recorded in DYN compared with STA and CTL (p ≤ 0.035). No changes were observed in NSE (p = 0.207) or hscTnT (p = 0.274).

Conclusions

Five repeated maximal DYN led to a greater muscle injury compared with STA but neither elicited myocardial injury or neuronal-parenchymal damage.

查看原文本刊更多论文

非潜水员在重复一系列静态和动态呼吸暂停后的压力生物标志物变化

本研究通过评估一系列与应激相关的生物标记物，研究了重复最大静态和动态呼吸暂停所造成的生理应变程度。方法七名健康男性在三个不同的场合（间隔≥72 小时）分别进行了：一系列五次重复最大 (i) 静态 (STA) 或 (ii) 动态呼吸暂停 (DYN) 或 (iii) 静态呼吸暂停方案 (CTL)。在每个方案后 30、90 和 180 分钟抽取静脉血样本，以测定缺血修饰白蛋白（IMA）、神经元特异性烯醇化酶（NSE）、肌红蛋白和高灵敏度心肌肌钙蛋白 T（hscTnT）的浓度。结果IMA 在呼吸暂停干预后升高（STA,+86%; DYN,+332%,p≤0.047 ），但 CTL 没有升高（p=0.385）。DYN 后 30 分钟，肌红蛋白高于基线（23.6±3.9 ng/mL）（+70%,38.8±13.3 ng/mL,p=0.030）。与 STA 和 CTL 相比，DYN 的肌红蛋白释放量更大（p≤0.035）。结论与 STA 相比，重复 5 次最大 DYN 会导致更大的肌肉损伤，但都不会引起心肌损伤或神经元-实质损伤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.