Cell competition and the regulation of protein homeostasis

IF 6 2区 生物学 Q1 CELL BIOLOGY
Shruthi Krishnan, Pranab K. Paul, Tristan A. Rodriguez
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引用次数: 0

Abstract

The process of embryonic development involves remarkable cellular plasticity, which governs the coordination between cells necessary to build an organism. One role of this plasticity is to ensure that when aberrant cells are eliminated, growth adjustment occurs so that the size of the tissue is maintained. An important regulator of cellular plasticity that ensures cellular cooperation is a fitness-sensing mechanism termed cell competition. During cell competition, cells with defects that lower fitness but do not affect viability, such as those that cause impaired signal transduction, slower cellular growth, mitochondrial dysregulation or impaired protein homeostasis, are killed when surrounded by fitter cells. This is accompanied by the compensatory proliferation of the surviving cells. The underlying factors and mechanisms that demarcate certain cells as less fit than their neighbouring cells and losers of cell competition are still relatively unknown. Recent evidence has pointed to mitochondrial defects and proteotoxic stress as important hallmarks of these loser cells. Here, we review recent advances in this area, focussing on the role of mitochondrial activity and protein homeostasis as major mechanisms determining competitive cell fitness during development and the importance of cell proteostasis in determining cell fitness.

细胞竞争与蛋白质平衡调节
胚胎发育过程涉及显著的细胞可塑性,这种可塑性控制着构建生物体所需的细胞之间的协调。这种可塑性的作用之一是确保当异常细胞被淘汰时,生长会发生调整,从而保持组织的大小。确保细胞合作的细胞可塑性的一个重要调节器是一种称为细胞竞争的适应感应机制。在细胞竞争过程中,有缺陷的细胞(如导致信号转导受损、细胞生长减慢、线粒体调节失调或蛋白质稳态受损的细胞)会降低适存性但不影响存活能力,当它们被更适存的细胞包围时就会被杀死。与此同时,存活下来的细胞会出现代偿性增殖。将某些细胞划分为体质较差的邻近细胞和细胞竞争失败者的潜在因素和机制仍相对未知。最近的证据表明,线粒体缺陷和蛋白毒性应激是这些失败者细胞的重要特征。在此,我们回顾了这一领域的最新进展,重点关注线粒体活性和蛋白质平衡作为决定发育过程中细胞竞争适应性的主要机制的作用,以及细胞蛋白稳态在决定细胞适应性方面的重要性。
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来源期刊
Current Opinion in Cell Biology
Current Opinion in Cell Biology 生物-细胞生物学
CiteScore
14.60
自引率
1.30%
发文量
79
审稿时长
93 days
期刊介绍: Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.
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